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Applications of Human Induced Pluripotent Stem Cell Derived Hepatocytes

  • Hua Liu
  • Pooja Chaudhari
  • Su Mi Choi
  • Yoon-Young Jang
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 3)

Abstract

Human induced pluripotent stem cells (iPSCs) are potential sources of hepatocytes for drug development and cell therapy. In vitro differentiation of iPSCs into hepatic cells has been achieved and improved during the last several years. More recently the in vivo functionality of human iPSC-derived hepatic cells at various differentiation stages has also been demonstrated. In this chapter, we describe the recent advance in human iPSC generation and hepatic differentiation technologies, the in vitro and in vivo activities of human iPSC derived hepatocytes, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening, drug discovery, gene therapy and cell replacement therapy.

Keywords

Pluripotent iPSCs Hepatocytes Liver Disease modeling Cell replacement therapy 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Hua Liu
    • 1
  • Pooja Chaudhari
    • 1
  • Su Mi Choi
    • 1
  • Yoon-Young Jang
    • 1
  1. 1.Stem Cell Biology Laboratory, The Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreUSA

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