Advertisement

Radiation Burns and Mesenchymal Stem Cell Therapy

  • Michel Drouet
  • Harry Scherthan
  • Viktor Meineke
  • Diane Agay
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 3)

Abstract

Cutaneous radiation syndrome (CRS) is the delayed consequence of localized skin and underlying tissue exposure to high doses of ionizing radiation (>20 Gy). CRS is characterized by extensive inflammation and a clinical evolution involving iterative inflammatory necrotic waves. Traditional treatment schedules for severe radiation burns are complex and can face a high mortality rate. A new treatment option by local injection of mesenchymal stem cells (MSCs) has been demonstrated to favour wound healing in various animal models via paracrinie and transdifferentiation. Recently, treatment success has been achieved in a few patients with severe radiation burns by combining surgery, skin autograph and MSC cell therapy.

Keywords

Stem cell therapy Radiation burns Animal models Cutaneous radiation syndrome 

References

  1. Agay D, Scherthan H, Forcheron F, Grenier N, Hérodin F, Meineke V, Drouet M (2010) Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: development of a new minipig model. Exp Hematol 38:945–956PubMedCrossRefGoogle Scholar
  2. Akita S, Akino K, Hirano A, Ohtsuru A, Yamashita S (2010) Mesenchymal stem cell therapy for cutaneous radiation syndrome. Health Phys 98:858–862PubMedCrossRefGoogle Scholar
  3. Altman AM, Yan Y, Mattias N, Bai X, Rios C, Mathur AB, Song Y-H, Alt EU (2009) IFATS collection: human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model. Stem Cells 27:250–258PubMedCrossRefGoogle Scholar
  4. Atiyeh BS, Costagliola M (2007) Cultured epithelial autograft (CEA) in burn treatment: three decades later. Burns 33:405–413PubMedCrossRefGoogle Scholar
  5. Badiavas EV, Abedi M, Butmarc J, Falanga V, Quesenberry P (2003) Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol 196:245–250PubMedCrossRefGoogle Scholar
  6. Benderitter M, Gourmelon P, Bey E, Chapel A, Clairand I, Prat M, Lataillade JJ (2010) New emerging concepts in the medical management of local radiation injury. Health Phys 98:851–857PubMedCrossRefGoogle Scholar
  7. Bey E, Prat M, Duhamel P, Benderitter M, Brachet M, Trompier F, Battaglini P, Ernou I, Boutin L, Gourven M, Tissedre F, Créa S, Ait Mansour C, de Revel T, Carsin H, Gourmelon P, Lataillade JJ (2010) Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cells administrations. Wound Rep Reg 18:50–58CrossRefGoogle Scholar
  8. Branski LK, Gauglitz GG, Herndon DN, Jescke MG (2009) A review of gene and stem cell therapy in cutaneous wound healing. Burns 35:171–180PubMedCrossRefGoogle Scholar
  9. Chamberlain G, Fox J, Ashton B, Middleton J (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25:2739–2749PubMedCrossRefGoogle Scholar
  10. Chambrette V, Hardy S, Nénot JC (2001) Les accidents d‘irradiation – mise en place d’une base de données “ACCIRAD” à l’IPSN. Radioprotection 36:477–501CrossRefGoogle Scholar
  11. Chapel A, Bertho JM, Bensidhoum M, Fouillard L, Young RG, Frick J, Demarquay C, Cuvelier F, Mathieu E, Trompier F, Dudoignon N, Germain C, Mazurier C, Aigueperse J, Borneman J, Gorin NC, Gourmelon P, Thierry D (2003) Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic stem cells to treat a radiation-induced multi-organ failure syndrome. J Gene Med 5:1028–1036PubMedCrossRefGoogle Scholar
  12. Chen L, Tredget EE, Wu PYG, Wu Y (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 3:e1886PubMedCrossRefGoogle Scholar
  13. Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R (2003) Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 101:2999–3001PubMedCrossRefGoogle Scholar
  14. Drouet M, Hérodin F (2010) Radiation victim management and the haematologist in the future: time to revisit therapeutic guidelines? Int J Radiat Biol 86:836–848CrossRefGoogle Scholar
  15. Ebrahimian TG, Pouzoulet F, Squiban C, Buard V, André B, Cousin P, Gourmelon P, Benderitter M, Casteilla R, Tamarat R (2009) Cell therapy based on adipose tissue-derived stromal cells promotes physical and pathological wound healing. Arterioscler Thromb Vasc Biol 29:503–510PubMedCrossRefGoogle Scholar
  16. Fliedner TM, Friesecke I, Beyrer K (eds) (2001) Medical management of radiation accidents: Manual on the acute radiation syndrome. British Inst of Radiology, London, pp 1–66Google Scholar
  17. François S, Bensidhoum M, Mouisseddine M, Mazurier C, Allenet B, Semont A, Frick J, Saché A, Bouchet S, Thierry D, Gourmelon P, Gorin NC, Chapel A (2006) Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage. Stem Cells 24:1020–1029PubMedCrossRefGoogle Scholar
  18. François S, Mouisseddine M, Mathieu N, Semont A, Monti P, Dudoignon N, Saché A, Boutarfa A, Thierry D, Gourmelon P, Chapel A (2007) Human mesenchymal stem cells favor healing of the cutaneous radiation syndrome in a xenogenic transplant model. Ann Hematol 86:1–8PubMedCrossRefGoogle Scholar
  19. Hopewell JW (1990) The skin: its structure and response to ionizing radiation. Int J Radiat Biol 57:751–773PubMedCrossRefGoogle Scholar
  20. Lataillade JJ, Doucet C, Bey E, Carsin H, Huet C, Clairand I, Bottolier-Depois JF, Chapel A, Ernou I, Gourven M, Boutin L, Hayden A, Carcamo C, Buglova E, Joussemet M, de Revel T, Gourmelon P (2007) New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen Med 2:785–794PubMedCrossRefGoogle Scholar
  21. Lau K, Paus R, Tied S, Day P, Bayat A (2009) Exploring the role of stem cells in cutaneous wound healing. Exp Dermatol 18:921–933PubMedCrossRefGoogle Scholar
  22. Lefaix JL, Delanian S (2005) Le syndrome cutané radio-induit. In: De Revel T, Gourmelon P, Vidal D, Renaudeau C (eds) The terrorist threat nuclear, radiological, biological, chemical- a medical approach. John Libbey Eurotext, Montrouge, pp 105–111Google Scholar
  23. Mahl JA, Vogel BE, Court M, Kolopp M, Roman D, Nogués V (2006) The minipig in dermatotoxicology: methods and challenges. Exp Toxicol Pathol 57:341–345PubMedCrossRefGoogle Scholar
  24. Nénot JC (2001) Les accidents d’irradiations, 1950-2000 Leçons du passé. Radioprotection 36:431–450CrossRefGoogle Scholar
  25. Peter RU (2005) Cutaneous radiation syndrome in multi-organ failure. Br J Radiol 27(Suppl 27):180–184CrossRefGoogle Scholar
  26. Phinney DG, Prockop DJ (2007) Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 25:2896–2902PubMedCrossRefGoogle Scholar
  27. Sasaki M, Abe R, Fujita Y, Ando S, Inokuma D, Shimizu H (2008) Mesenchymal stem cells are recruited into wound skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 180:2581–2587PubMedGoogle Scholar
  28. Schäffler A, Büchler C (2007) Concise review: adipose tissue-derived stromal cells-basic and clinical implications for novel cell-based therapies. Stem Cells 25:818–827PubMedCrossRefGoogle Scholar
  29. Tarte K, Gaillard J, Lataillade JJ, Fouillard L, Becker M, Mossafa H, Tchirkov A, Rouard H, Henry C, Splingard M, Dulong J, Monnier D, Gourmelon P, Gorin NC, Sensebé L (2010) Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. Blood 115:1549–1553PubMedCrossRefGoogle Scholar
  30. Tolar J, Le Blanc K, Keating A, Blazar BR (2010) Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells 28:1446–1455PubMedCrossRefGoogle Scholar
  31. Trottier V, Marceau-Fortier G, Germain L, Vincent C, Fradette J (2008) IFATS collection: using human adipose-derived stem/stromal cells for the production of new skin substitutes. Stem Cells 26:2713–2723PubMedCrossRefGoogle Scholar
  32. Turai I, Vress K, Günalp B, Souchkevitch G (2004) Medical response to radiation incidents and radionuclear threats. BMJ 328:568–572PubMedCrossRefGoogle Scholar
  33. Wu Y, Chen L, Scott PG, Tredget EE (2007) Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 25:2648–2659PubMedCrossRefGoogle Scholar
  34. Zuk PA (2010) The adipose-derived stem cell: looking back and looking ahead. Mol Biol Cell 21:1783–1787PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Michel Drouet
    • 1
  • Harry Scherthan
    • 2
  • Viktor Meineke
    • 2
  • Diane Agay
    • 3
  1. 1.Head of Cell Therapy Unit IRBA-CRSSALa TroncheFrance
  2. 2.Institut für Radiobiologie der Bundeswehr in Verbindung mit der Universität UlmMünchenGermany
  3. 3.IRBA-CRSSALa TroncheFrance

Personalised recommendations