Radiation Burns and Mesenchymal Stem Cell Therapy

  • Michel Drouet
  • Harry Scherthan
  • Viktor Meineke
  • Diane Agay
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 3)


Cutaneous radiation syndrome (CRS) is the delayed consequence of localized skin and underlying tissue exposure to high doses of ionizing radiation (>20 Gy). CRS is characterized by extensive inflammation and a clinical evolution involving iterative inflammatory necrotic waves. Traditional treatment schedules for severe radiation burns are complex and can face a high mortality rate. A new treatment option by local injection of mesenchymal stem cells (MSCs) has been demonstrated to favour wound healing in various animal models via paracrinie and transdifferentiation. Recently, treatment success has been achieved in a few patients with severe radiation burns by combining surgery, skin autograph and MSC cell therapy.


Stem cell therapy Radiation burns Animal models Cutaneous radiation syndrome 


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Michel Drouet
    • 1
  • Harry Scherthan
    • 2
  • Viktor Meineke
    • 2
  • Diane Agay
    • 3
  1. 1.Head of Cell Therapy Unit IRBA-CRSSALa TroncheFrance
  2. 2.Institut für Radiobiologie der Bundeswehr in Verbindung mit der Universität UlmMünchenGermany
  3. 3.IRBA-CRSSALa TroncheFrance

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