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Water Soluble Vitamins pp 229–245Cite as

Riboflavin in Development and Cell Fate

Part of the Subcellular Biochemistry book series (SCBI,volume 56)

Abstract

Riboflavin (7,8-dimethyl-10-ribitylisoalloxazine; vitamin B2) is a water-soluble vitamin, cofactor derivatives of which (FAD, FMN) act as electron acceptors in the oxidative metabolism of carbohydrate, amino acids and fatty acids and which in the reduced state can donate electrons to complex II of the electron transport chain. This means that riboflavin is essential for energy generation in the aerobic cell, through oxidative phosphorylation. The classic effects of riboflavin deficiency on growth and development have generally been explained in terms of these functions. However, research also suggests that riboflavin may have specific functions associated with cell fate determination, which would have implications for growth and development. In particular, riboflavin depletion interferes with the normal progression of the cell cycle, probably through effects on the expression of regulatory genes, exerted at both the transcriptional and proteomic level.

Keywords

  • Riboflavin
  • Cell fate
  • Gene expression
  • Cell cycle

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Authors and Affiliations

  1. Human Nutrition Unit, The School of Medicine, The University of Sheffield, Sheffield, S10 2RX, UK

    Hilary J. Powers

  2. Human Nutrition Unit, The School of Medicine, The University of Sheffield, Sheffield, S10 2RX, UK

    B.M. Corfe & E. Nakano

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  1. Hilary J. Powers
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  2. B.M. Corfe
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  3. E. Nakano
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Correspondence to Hilary J. Powers .

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  1. Imperial College of Science, Technology and Medicine, Royal Brompton & Harefield NHS Foundatio, Sydney Street, London, SW3 6NP, United Kingdom

    Olaf Stanger

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Powers, H.J., Corfe, B., Nakano, E. (2012). Riboflavin in Development and Cell Fate. In: Stanger, O. (eds) Water Soluble Vitamins. Subcellular Biochemistry, vol 56. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2199-9_12

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