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Interplay between Metal Ions and Nucleic Acids pp 319–340Cite as

Metal Complex Derivatives of Peptide Nucleic Acids (PNA)

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Part of the book series: Metal Ions in Life Sciences ((MILS,volume 10))

Abstract

Peptide nucleic acid (PNA) is a non-cyclic pseudopeptide-nucleic acid structural mimic with promising applications within diagnostics and drug discovery. This review focuses on metal complex derivatives of PNA. Metal ions and their complexes display unique physical and chemical properties and offer the opportunity to introduce new labels and probes for bioanalytical and diagnostic applications of PNA, but also to modulate or to introduce new (for example catalytic) functions and biological activities.

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Authors and Affiliations

  1. Inorganic Chemistry Institute, University of Heidelberg, Im Neuenheimer Feld 270, D-69120, Heidelberg, Germany

    Roland Krämer & Andriy Mokhir

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  1. Roland Krämer
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  2. Andriy Mokhir
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Correspondence to Roland Krämer .

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Editors and Affiliations

  1. Inorganic Chemistry, Chemistry, Universität Basel, Spitalstr. 51, Basel, 4056, Basel Stadt, Switzerland

    Astrid Sigel

  2. Inorganic Chemistry, Chemistry, Universität Basel, Spitalstr. 51, Basel, 4056, Basel Stadt, Switzerland

    Helmut Sigel

  3. Organisch-Chemisches Institut, Universität Zürich, Winterthurerstrasse 190, Zürich, 8057, Switzerland

    Roland K. O. Sigel

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Krämer, R., Mokhir, A. (2012). Metal Complex Derivatives of Peptide Nucleic Acids (PNA). In: Sigel, A., Sigel, H., Sigel, R. (eds) Interplay between Metal Ions and Nucleic Acids. Metal Ions in Life Sciences, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2172-2_12

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