Molecular Typing of Bacterial Pathogens: A Tool for the Epidemiological Study and Control of Infectious Diseases

  • Marie HallinEmail author
  • Ariane Deplano
  • Marc J. Struelens


Molecular typing is nowadays an integral part of the public health microbiology toolbox. It indexes subspecies genotypic or phenotypic characters to estimate the genetic relatedness of microbial isolates and infer from it their probability of belonging to the same chain of transmission. Typing is used both to investigate outbreaks and enhance the resolution of disease surveillance at different population levels: (i) locally, in hospitals or the community, by clinical or public health laboratories; (ii) nationally, by reference laboratories or (iii) globally, through international surveillance networks. This chapter provides an overview of currently available and emerging technologies for typing human bacterial pathogens, discusses their suitability to different levels of use and reviews examples of integrated typing in advanced surveillance systems.


Typing Method Multi Locus Sequencing Typing Epidemiological Typing Human Bacterial Pathogen Multiple Locus VNTR Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Marie Hallin
    • 1
    Email author
  • Ariane Deplano
    • 1
  • Marc J. Struelens
    • 2
  1. 1.Laboratoire de Microbiologie et Laboratoire de Référence des Staphylocoques-MRSAHôpital ErasmeBrusselsBelgium
  2. 2.Scientific Advice UnitEuropean Centre for Disease Prevention and ControlStockholmSweden

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