Skip to main content
SpringerLink
Log in

Heat Shock Proteins: The Minimal, but Universal, Stress Proteome

  • Chapter
  • First Online:
Book cover Stress Ecology

Abstract

The initial observation that led to the discovery of the heat shock proteins (HSPs) was that heat shock generated focal swellings or “puffs” on chromosomes of Drosophila salivary glands (Roberts et al. 2010). Such swellings were recognized as indicating that genes were being activated in those areas of the genome to give rise to their encoded proteins. These therefore became known as the “heat shock loci” and were initially considered a phenomenon unique to fruitflies. It was not until 1974 that these loci were proven the sites of transcriptional induction of genes encoding for a particular group of proteins, which were designated HSPs. It was even longer before it was recognized that they occurred in mammals and indeed at all evolutionary levels (Lindquist and Craig 1988).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahamed M, Posgai R, Gorey TJ, Nielsen M, Hussain SM, Rowe JJ (2010) Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol 242:263–269

    Article  PubMed  CAS  Google Scholar 

  • Ainsworth EA, Rogers A (2007) The response of photosynthesis and stomatal conductance to rising [CO2]: mechanisms and environmental interactions. Plant Cell Environ 30:258–270

    Article  PubMed  CAS  Google Scholar 

  • Ait-Aissa S, Porcher JM, Arrigo AP, Lambre C (2000) Activation of the hsp70 promoter by environmental inorganic and organic chemicals: relationships with cytotoxicity and lipophilicity. Toxicology 145:147–157

    Article  PubMed  CAS  Google Scholar 

  • Alamillo J, Almoguera C, Bartels D, Jordano J (1995) Constitutive expression of small heat shock proteins in vegetative tissues of the resurrection plant Craterostigma plantagineum. Plant Mol Biol 29:1093–1099

    Article  PubMed  CAS  Google Scholar 

  • Anestis A, Pörtner HO, Lazou A, Michaelidis B (2008) Metabolic and molecular stress responses of sublittoral bearded horse mussel Modiolus barbatus to warming sea water: implications for vertical zonation. J Ex Biol 211:2889–2898

    Article  CAS  Google Scholar 

  • Arsène F, Tomoyasu T, Bukau B (2000) The heat shock response of Escherichia coli. Int J Food Microbiol 55:3–9

    Article  PubMed  Google Scholar 

  • Baird NA, Turnbull DW, Johnson EA (2006) Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. J Biol Chem 281:38675–38681

    Article  PubMed  CAS  Google Scholar 

  • Baniwal SK, Bharti K, Chan KY, Fauth M, Ganguli A, Kotak S, Mishra SK, Nover L, Port M, Scharf KD, Tripp J, Weber C, Zielinski D (2004) Heat stress response in plants: a complex game with chaperones and more than twenty heat stress transcription factors. J Biosci 29:471–487

    Article  PubMed  CAS  Google Scholar 

  • Bedulina DS, Timofeyev MA, Zimmer M, Zwirnmann E, Menzel R, Steinberg CEW (2010a) Different natural organic matter isolates cause similar stress response patterns in the freshwater amphipod, Gammarus pulex. Environ Sci Pollut Res 17:261–269

    Article  CAS  Google Scholar 

  • Bedulina DS, Zimmer M, Timofeyev MA (2010b) Sub-littoral and supra-littoral amphipods respond differently to acute thermal stress. Comp Biochem Physiol B Biochem Mol Biol 155:413–418

    Article  PubMed  CAS  Google Scholar 

  • Bosch TCG, Krylow SM, Bode HR, Steele RE (1988) Thermotolerance and synthesis of heat shock proteins: these responses are present in Hydra attenuata but absent in Hydra oligactis. Proc Natl Acad Sci USA 85:7927–7931

    Article  PubMed  CAS  Google Scholar 

  • Bourgeon S, Martínez J, Criscuolo F, Le Maho Y, Raclot T (2006) Fasting-induced changes of immunological and stress indicators in breeding female eiders. Gen Comp Endocrinol 147:336–342

    Article  PubMed  CAS  Google Scholar 

  • Brennecke T, Gellner K, Bosch TCG (1998) The belt of a stress response in Hydra oligactis is due to reduced hsp70 mRNA stability. Eur J Biochem 255:703–709

    Article  PubMed  CAS  Google Scholar 

  • Brown DA, Johnson MS, Armstrong CJ, Lynch JM, Caruso NM, Ehlers LB, Fleshner M, Spencer RL, Moore RL (2007) Short-term treadmill running in the rat: what kind of stressor is it? J Appl Physiol 103:1979–1985

    Article  PubMed  Google Scholar 

  • Brulle F, Mitta G, Cocquerelle C, Vieau D, Lemière S, Leprêtre A, Vandenbulcke F (2006) Cloning and real-time PCR testing of 14 potential biomarkers in Eisenia fetida following cadmium exposure. Environ Sci Technol 40:2844–2850

    Article  PubMed  CAS  Google Scholar 

  • Cheng CHC, Detrich HW III (2007) Molecular ecophysiology of Antarctic notothenioid fishes. Philos Trans R Soc B 362:2215–2232

    Article  CAS  Google Scholar 

  • Colinet H, Lee SF, Hoffmann A (2010) Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster. FEBS J 277:174–185

    Article  PubMed  CAS  Google Scholar 

  • Collins PL, Hightower LE (1982) Newcastle disease virus stimulates the cellular accumulation of stress (heat-shock) messenger-RNAs and proteins. J Virol 44:703–707

    PubMed  CAS  Google Scholar 

  • Currie S, Bagatto B, DeMille M, Learner A, LeBlanc D, Marks C, Ong K, Parker J, Templeman N, Tufts BL, Wright PA (2010) Metabolism, nitrogen excretion, and heat shock proteins in the central mudminnow (Umbra limi), a facultative air-breathing fish living in a variable environment. Can J Zool 88:43–58

    Article  CAS  Google Scholar 

  • Dahlhoff EP (2004) Biochemical indicators of stress and metabolism: applications for marine ecological studies. Annu Rev Physiol 66:183–207

    Article  PubMed  CAS  Google Scholar 

  • Denekamp NY, Thorne MAS, Clark MS, Kube M, Reinhardt R, Lubzens E (2009) Discovering genes associated with dormancy in the monogonont rotifer Brachionus plicatilis. BMC Genomics 10:108

    Article  PubMed  CAS  Google Scholar 

  • Diamant S, Eliahu N, Rosenthal D, Goloubinoff P (2001) Chemical chaperones regulate molecular chaperones in vitro and in cells under combined salt and heat stresses. J Biol Chem 276:39586–39591

    Article  PubMed  CAS  Google Scholar 

  • Dietz TJ, Somero GN (1992) The threshold induction temperature of the 90-kDa heat shock protein is subject to acclimatization in eurythermal goby fishes (genus Gillichthys). Proc Natl Acad Sci USA 89:3389–3393

    Article  PubMed  CAS  Google Scholar 

  • Donaldson MR, Cooke SJ, Patterson DA, Macdonald JS (2008) Cold shock and fish. J Fish Biol 73:1491–1530

    Article  Google Scholar 

  • Drew B, Miller D, Toop T, Hanna P (2001) Identification of expressed HSP’s in blacklip abalone (Haliotis rubra Leach) during heat and salinity stresses. J Shellfish Res 20:695–703

    Google Scholar 

  • Duncan RF (2005) Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J 272:5244–5256

    Article  PubMed  CAS  Google Scholar 

  • Eckwert H, Köhler HR (1997) The indicative value of the hsp70 stress response as a marker for metal effects in Oniscus asellus (Isopoda) field populations: variability between populations from metal-polluted and uncontaminated sites. Appl Soil Ecol 6:275–282

    Article  Google Scholar 

  • Eder KJ, Köhler HR, Werner I (2007) Pesticide and pathogen: heat shock protein expression and acetylcholinesterase inhibition in juvenile Chinook salmon in response to multiple stressors. Environ Toxicol Chem 26:1233–1242

    Article  PubMed  CAS  Google Scholar 

  • Feder ME, Hofmann GE (1999) Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol 61:243–282

    Article  PubMed  CAS  Google Scholar 

  • Feder ME, Cartano NV, Milos L, Krebs RA, Lindquist SL (1996) Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. J Exp Biol 199:1837–1844

    PubMed  CAS  Google Scholar 

  • Fehrenbach E, Niess AH (1999) Role of heat shock proteins in the exercise response. Exerc Immunol Rev 5:57–77

    PubMed  CAS  Google Scholar 

  • Fleshner M, Campisi J, Amiri L, Diamond DM (2004) Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones. Psychoneuroendocrinology 29:1142–1152

    Article  PubMed  CAS  Google Scholar 

  • Geissler N, Hussin S, Koyro HW (2010) Elevated atmospheric CO2 concentration enhances salinity tolerance in Aster tripolium L. Planta 231:583–594

    Article  PubMed  CAS  Google Scholar 

  • Gellner K, Praetzel G, Bosch TCG (1992) Cloning and expression of a heat-inducible hsp70 gene in two species of Hydra which differ in their stress response. Eur J Biochem 210:683–691

    Article  PubMed  CAS  Google Scholar 

  • Gophna U, Ron EZ (2003) Virulence and the heat shock response. Int J Med Microbiol 292:453–461

    Article  PubMed  CAS  Google Scholar 

  • Goto SG, Yoshida KM, Kimura MT (1998) Accumulation of Hsp70 mRNA under environmental stresses in diapausing and nondiapausing adults of Drosophila triauraria. J Insect Physiol 44:1009–1015

    Article  PubMed  CAS  Google Scholar 

  • Haap T, Köhler HR (2009) Cadmium tolerance in seven Daphnia magna clones is associated with reduced hsp70 baseline levels and induction. Aquat Toxicol 94:131–137

    Article  PubMed  CAS  Google Scholar 

  • Hamilton EW, McNaughton SJ, Coleman JS (2001) Molecular, physiological, and growth responses to sodium stress in C-4 grasses from a soil salinity gradient in the Serengeti ecosystem. Am J Bot 88:1258–1265

    Article  CAS  Google Scholar 

  • Hansen AC, Rosenlund G, Karlsen Ø, Olsvik PA, Hemre GI (2006) The inclusion of plant protein in cod diets, its effects on macronutrient digestibility, gut and liver histology and heat shock protein transcription. Aquacult Res 37:773–784

    Article  CAS  Google Scholar 

  • Hao X, Zhang S, Timakov B, Zhang P (2007) The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance. Cell Stress Chaperones 12:364–372

    Article  PubMed  CAS  Google Scholar 

  • Hayward SAL, Rinehart JP, Denlinger DL (2004) Desiccation and rehydration elicit distinct heat shock protein transcript responses in flesh fly pupae. J Exp Biol 207:963–971

    Article  PubMed  CAS  Google Scholar 

  • Heidler T, Hartwig K, Daniel H, Wenzel U (2010) Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. Biogerontology 11:183–195

    Article  PubMed  CAS  Google Scholar 

  • Hercus MJ, Loeschcke V, Rattan SIS (2003) Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress. Biogerontology 4:149–156

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann AA, Sørensen JG, Loeschcke V (2003) Adaptation of Drosophila to temperature extremes: bringing together quantitative and molecular approaches. J Therm Biol 28:175–216

    Article  Google Scholar 

  • Hofmann GE (2005) Patterns of Hsp gene expression in ectothermic marine organisms on small to large biogeographic scales. Integr Comp Biol 45:247–255

    Article  PubMed  CAS  Google Scholar 

  • Hofmann GE, Buckley BA, Airaksinen S, Keen JE, Somero GN (2000) Heat-shock protein expression is absent in the Antarctic fish Trematomus bernacchii (family Nototheniidae). J Exp Biol 203:2331–2339

    PubMed  CAS  Google Scholar 

  • Hofmann GE, Buckley BA, Place SP, Zippay ML (2002) Molecular chaperones in ectothermic marine animals: biochemical function and gene expression. Integr Comp Biol 42:808–814

    Article  PubMed  CAS  Google Scholar 

  • Hofmann GE, Lund SG, Place SP, Whitmer AC (2005) Some like it hot, some like it cold: The heat shock response is found in New Zealand but not Antarctic notothenioid fishes. J Exp Mar Biol Ecol 316:79–89

    Article  CAS  Google Scholar 

  • Ittiprasert W, Nene R, Miller A, Raghavan N, Lewis F, Hodgson J, Knight M (2009) Schistosoma mansoni infection of juvenile Biomphalaria glabrata induces a differential stress response between resistant and susceptible snails. Exp Parasitol 123:203–211

    Article  PubMed  CAS  Google Scholar 

  • Jenkins ME, Suzuki TC, Mount DW (1997) Evidence that heat and ultraviolet radiation activate a common stress-response program in plants that is altered in the uvh6 mutant of Arabidopsis thaliana. Plant Physiol 115:1351–1358

    Article  PubMed  CAS  Google Scholar 

  • Kagawa N, Mugiya Y (2002) Brain HSP70 mRNA expression is linked with plasma cortisol levels in goldfish (Carassius auratus) exposed to a potential predator. Zool Sci 19:735–740

    Article  PubMed  CAS  Google Scholar 

  • Kagawa N, Ryo K, Mugiya Y (1999) Enhanced expression of stress protein 70 in the brains of goldfish, Carassius auratus, reared with bluegills, Lepomis macrochirus. Fish Physiol Biochem 21:103–110

    Article  CAS  Google Scholar 

  • Karl I, Sørensen JG, Loeschcke V, Fischer K (2009) HSP70 expression in the Copper butterfly Lycaena tityrus across altitudes and temperatures. J Evol Biol 22:172–178

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann SHE, Schoel B (1994) Heat shock proteins as antigens in immunity against infection and self. In: Morimoto RI, Tissières A, Georgopoulos C (eds) The biology of heat shock proteins and molecular chaperones. Cold Spring Harbor Laboratory Press, Cold Spring Harbor

    Google Scholar 

  • Kiriyama MT, Oka M, Takehana M, Kobayashi S (2001) Expression of a small heat shock protein 27 (HSP27) in mouse skin tumors induced by UVB-irradiation. Biol Pharm Bull 24:197–200

    Article  PubMed  CAS  Google Scholar 

  • Köhler HR, Eckwert H (1997) The induction of stress proteins (hsp) in Oniscus asellus (Isopoda) as a molecular marker of multiple heavy metal exposure. 2. Joint toxicity and transfer to field situations. Ecotoxicology 6:263–274

    Article  Google Scholar 

  • Krebs RA, Feder ME (1997) Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae. Cell Stress Chaperones 2:60–71

    Article  PubMed  CAS  Google Scholar 

  • Krebs RA, Feder ME (1998) Experimental manipulation of the cost of thermal acclimation in Drosophila melanogaster. Biol J Linn Soc 63:593–601

    Google Scholar 

  • Krebs RA, Loeschcke V (1994) Costs and benefits of activation of the heat-shock response in Drosophila melanogaster. Funct Ecol 8:730–737

    Article  Google Scholar 

  • Kristensen TN, Hoffmann AA, Overgaard J, Sørensen JG, Hallas R, Loeschcke V (2008) Costs and benefits of cold acclimation in field-released Drosophila. Proc Natl Acad Sci USA 105:216–221

    Article  PubMed  CAS  Google Scholar 

  • Kültz D (2005) Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol 67:225–257

    Article  PubMed  CAS  Google Scholar 

  • La Porte PF (2005) Mytilus trossulus hsp70 as a biomarker for arsenic exposure in the marine environment: laboratory and real-world results. Biomarkers 10:417–428

    Article  PubMed  CAS  Google Scholar 

  • Lee SM, Lee SB, Park CH, Choi J (2006) Expression of heat shock protein and hemoglobin genes in Chironomus tentans (Diptera, chironomidae) larvae exposed to various environmental pollutants: a potential biomarker of freshwater monitoring. Chemosphere 65:1074–1081

    Article  PubMed  CAS  Google Scholar 

  • Lesser MP, Bailey MA, Merselis DG, Morrison JR (2010) Physiological response of the blue mussel Mytilus edulis to differences in food and temperature in the Gulf of Maine. Comp Biochem Physiol A Mol Integr Physiol 156:541–551

    Article  PubMed  CAS  Google Scholar 

  • Li QB, Haskell DW, Guy CL (1999) Coordinate and noncoordinate expression of the stress 70 family and other molecular chaperones at high and low temperature in spinach and tomato. Plant Mol Biol 39:21–34

    Article  PubMed  Google Scholar 

  • Lim B, Gross CA (2011) Cellular response to heat shock and cold shock. In: Storz G, Hengge R (eds) Bacterial stress response, 2nd edn. ASM Press, Washington, DC, pp 93–114

    Google Scholar 

  • Lima SL (1998) Stress and decision making under the risk of predation: recent developments from behavioral, reproductive, and ecological perspectives. Adv Study Behav 27:215–290

    Article  Google Scholar 

  • Lindquist S (1986) The heat-shock response. Annu Rev Biochem 55:1151–1191

    Article  PubMed  CAS  Google Scholar 

  • Lindquist S, Craig EA (1988) The heat-shock proteins. Annu Rev Genet 22:631–677

    Article  PubMed  CAS  Google Scholar 

  • Ma E, Haddad GG (1997) Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster. Mol Brain Res 46:325–328

    Article  PubMed  CAS  Google Scholar 

  • Martinez J, Perez-Serrano J, Bernadina WE, Rodriguez-Caabeiro F (2001) Stress response to cold in Trichinella species. Cryobiology 43:293–302

    Article  PubMed  CAS  Google Scholar 

  • Martínez-Padilla J, Martínez J, Dávila JA, Merino S, Moreno J, Millán J (2004) Within-brood size differences, sex and parasites determine blood stress protein levels in Eurasian Kestrel nestlings. Funct Ecol 18:426–434

    Article  Google Scholar 

  • Merino S, Martinez J, Barbosa A, Møller AP, De Lope F, Pérez J, Rodríguez-Caabeiro F (1998) Increase in a heat-shock protein from blood cells in response of nestling house martins (Delichon urbica) to parasitism: an experimental approach. Oecologia 116:343–347

    Article  Google Scholar 

  • Merino S, Martínez J, Møller AP, Barbosa A, de Lope F, Rodríguez-Caabeiro F (2002) Blood stress protein levels in relation to sex and parasitism of barn swallows (Hirundo rustica). Ecoscience 9:300–305

    Google Scholar 

  • Merino S, Moreno J, Tomás G, Martínez J, Morales J, Martínez-De La Puente J, Osorno JL (2006) Effects of parental effort on blood stress protein HSP60 and immunoglobulins in female blue tits: a brood size manipulation experiment. J Anim Ecol 75:1147–1153

    Article  PubMed  Google Scholar 

  • Mikulski A, Grzesiuk M, Kloc M, Pijanowska J (2009) Heat shock proteins in Daphnia detected using commercial antibodies: description and responsiveness to thermal stress. Chemoecology 19:69–72

    Article  CAS  Google Scholar 

  • Mizrahi T, Heller J, Goldenberg S, Arad Z (2009) Heat shock proteins and resistance to desiccation in congeneric land snails. Cell Stress Chaperones 15:351–363

    Article  PubMed  CAS  Google Scholar 

  • Nickerson M, Elphick GF, Campisi J, Greenwood BN, Fleshner M (2005) Physical activity alters the brain Hsp72 and IL-1β responses to peripheral E. coli challenge. Am J Physiol Regul Integr Comp Physiol 289:R1665–R1674

    Article  PubMed  CAS  Google Scholar 

  • Otsuka Y, Takano TS, Yamazaki T (1997) Genetic variation in the expression of the six hsp genes in the presence of heat shock in Drosophila melanogaster. Genes Genet Syst 72:19–24

    Article  PubMed  CAS  Google Scholar 

  • Paul A, Hackbarth S, Vogt RD, Röder B, Burnison BK, Steinberg CEW (2004) Photogeneration of singlet oxygen by humic substances: comparison of humic substances of aquatic and terrestrial origin. Photochem Photobiol Sci 3:272–280

    Article  CAS  Google Scholar 

  • Pauwels K, Stoks R, de Meester L (2005) Coping with predator stress: intercolonal differences in induction of heat-shock proteins in the water flea Daphnia magna. J Evol Biol 18:867–872

    Article  PubMed  CAS  Google Scholar 

  • Pauwels K, Stoks R, Decaestecker E, de Meester L (2007) Evolution of heat shock protein expression in a natural population of Daphnia magna. Am Nat 170:800–805

    Article  PubMed  Google Scholar 

  • Pauwels K, De Meesters L, Put S, Decaestecker E, Stoks R (2010a) Rapid evolution of phenoloxidase expression, a component of innate immune function, in a natural population of Daphnia magna. Limnol Oceanogr 55:1408–1413

    Article  CAS  Google Scholar 

  • Pijanowska J, Kloc M (2004) Daphnia response to predation threat involves heat-shock proteins and the actin and tubulin cytoskeleton. Genesis 38:81–86

    Article  PubMed  CAS  Google Scholar 

  • Pinsino A, Thorndyke MC, Matranga V (2007) Coelomocytes and post-traumatic response in the common sea star Asterias rubens. Cell Stress Chaperones 12:331–341

    Article  PubMed  CAS  Google Scholar 

  • Place SP, Hofmann GE (2005) Constitutive expression of a stress-inducible heat shock protein gene, hsp70, in phylogenetically distant Antarctic fish. Polar Biol 28:261–267

    Article  Google Scholar 

  • Pockley AG (2003) Heat shock proteins as regulators of the immune response. Lancet 362:469–476

    Article  PubMed  CAS  Google Scholar 

  • Rinehart JP, Denlinger DL, Rivers DB (2002) Upregulation of transcripts encoding select heat shock proteins in the flesh fly Sarcophaga crassipalpis in response to venom from the ectoparasitoid wasp Nasonia vitripennis. J Invertebr Pathol 79:62–63

    Article  PubMed  CAS  Google Scholar 

  • Roberts RJ, Agius C, Saliba C, Bossier P, Sung YY (2010) Heat shock proteins (chaperones) in fish and shellfish and their potential role in relation to fish health: a review. J Fish Dis 33:789–801

    Article  PubMed  CAS  Google Scholar 

  • Ropp M, Courgeon AM, Calvayrac R, Bestbelpomme M (1983) The possible role of the superoxide ion in the induction of heat-shock and specific proteins in aerobic Drosophila cells during return to normoxia after a period of anaerobiosis. Can J Biochem Cell Biol 61:456–461

    Article  PubMed  CAS  Google Scholar 

  • Rutherford SL (2003) Between genotype and phenotype: protein chaperones and evolvability. Nat Rev Genet 4:263–274

    Article  PubMed  CAS  Google Scholar 

  • Sales K, Brandt W, Rumbak E, Lindsey G (2000) The LEA-like protein HSP 12 in Saccharomyces cerevisiae has a plasma membrane location and protects membranes against desiccation and ethanol-induced stress. Biochim Biophys Acta Biomembr 1463:267–278

    Article  CAS  Google Scholar 

  • Scheil V, Zürn A, Köhler HR, Triebskorn R (2010) Embryo development, stress protein (Hsp70) responses, and histopathology in zebrafish (Danio rerio) following exposure to nickel chloride, chlorpyrifos, and binary mixtures of them. Environ Toxicol 25:83–93

    PubMed  CAS  Google Scholar 

  • Schokraie E, Hotz-Wagenblatt A, Warnken U, Frohme M, Dandekar T, Schill RO, Schnölzer M (2011) Investigating heat shock proteins of tardigrades in active versus anhydrobiotic state using shotgun proteomics. J Zool Syst Evol Res 49(Suppl 1):111–119

    Article  Google Scholar 

  • Schröder HC, Batel R, Lauenroth S, Hassanein HMA, Lacorn M, Simat T, Steinhart H, Müller WEG (1999) Induction of DNA damage and expression of heat shock protein HSP70 by polychlorinated biphenyls in the marine sponge Suberites domuncula Olivi. J Exp Mar Biol Ecol 233:285–300

    Article  Google Scholar 

  • Sejerkilde M, Sørensen JG, Loeschcke V (2003) Effects of cold- and heat-hardening on thermal resistance and Hsp70 expression in Drosophila melanogaster. J Insect Physiol 49:719–726

    Article  PubMed  CAS  Google Scholar 

  • Sharma S, Singh R, Kaur M, Kaur G (2010) Late-onset dietary restriction compensates for age-related increase in oxidative stress and alterations of HSP 70 and synapsin1 protein levels in male Wistar rats. Biogerontology 11:197–209

    Article  PubMed  CAS  Google Scholar 

  • Silbermann R, Tatar M (2000) Reproductive costs of heat shock protein in transgenic Drosophila melanogaster. Evolution 54:2038–2045

    PubMed  CAS  Google Scholar 

  • Sinclair BJ, Gibbs AG, Roberts SP (2007) Gene transcription during exposure to, and recovery from, cold and desiccation stress in Drosophila melanogaster. Insect Mol Biol 16:435–443

    Article  PubMed  CAS  Google Scholar 

  • Skidmore R, Gutierrez JA, Guerriero V, Kregel KC (1995) Hsp70 induction during exercise and heat-stress in rats – role of internal temperature. Am J Physiol Regul Integr Comp Physiol 37:R92–R97

    Google Scholar 

  • Slos S, Stoks R (2008) Predation risk induces stress proteins and reduces antioxidant defense. Funct Ecol 22:637–642

    Article  Google Scholar 

  • Song L, Wu L, Ni D, Chang Y, Xu W, Xing K (2006) The cDNA cloning and mRNA expression of heat shock protein 70 gene in the haemocytes of bay scallop (Argopecten irradians, Lamarck 1819) responding to bacteria challenge and naphthalin stress. Fish Shellfish Immunol 21:335–345

    Article  PubMed  CAS  Google Scholar 

  • Sonna LA, Fujita J, Gaffin SL, Lilly CM (2002) Invited review: effects of heat and cold stress on mammalian gene expression. J Appl Physiol 92:1725–1742

    PubMed  CAS  Google Scholar 

  • Soosaar JLM, Burch-Smith TM, Dinesh-Kumar SP (2005) Mechanisms of plant resistance to viruses. Nat Rev Microbiol 3:789–798

    Article  PubMed  CAS  Google Scholar 

  • Sørensen JG, Loeschcke V (2001) Larval crowding in Drosophila melanogaster induces Hsp70 expression, and leads to increased adult longevity and adult thermal stress resistance. J Insect Physiol 47:1301–1307

    Article  PubMed  Google Scholar 

  • Sørensen JG, Dahlgaard J, Loeschcke V (2001) Genetic variation in thermal tolerance among natural populations of Drosophila buzzatii: down regulation of Hsp70 expression and variation in heat stress resistance traits. Funct Ecol 15:289–296

    Article  Google Scholar 

  • Sørensen JG, Kristensen TN, Loeschcke V (2003) The evolutionary and ecological role of heat shock proteins. Ecol Lett 6:1025–1037

    Article  Google Scholar 

  • Spees JL, Chang SA, Snyder MJ, Chang ES (2002) Osmotic induction of stress-responsive gene expression in the lobster Homarus americanus. Biol Bull 203:331–337

    Article  PubMed  CAS  Google Scholar 

  • Steinberg CEW, Saul N, Pietsch K, Meinelt T, Rienau S, Menzel R (2007) Dissolved humic substances facilitate fish life in extreme aquatic environments and have the potential to extend lifespan of Caenorhabditis elegans. Ann Environ Sci 1:81–90

    CAS  Google Scholar 

  • Steinberg CEW, Ouerghemmi N, Herrmann S, Bouchnak R, Timofeyev MA, Menzel R (2010a) Stress by poor food quality and exposure to humic substances: Daphnia magna responds with oxidative stress, lifespan extension, but reduced offspring numbers. Hydrobiologia 652:223–236

    Article  CAS  Google Scholar 

  • Steinert SA, Pickwell GV (1993) Induction of Hsp70-proteins in mussels by ingestion of tributyltin. Mar Environ Res 35:89–93

    Article  CAS  Google Scholar 

  • Sures B, Radszuweit H (2007) Pollution-induced heat shock protein expression in the amphipod Gammarus roeseli is affected by larvae of Polymorphus minutus (Acanthocephala). J Helminthol 81:191–197

    Article  PubMed  CAS  Google Scholar 

  • Swindell WR, Huebner M, Weber AP (2007) Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways. BMC Genomics 8:125

    Article  PubMed  CAS  Google Scholar 

  • Takahashi KH, Rako L, Takano-Shimizu T, Hoffmann AA, Lee SF (2010) Effects of small Hsp genes on developmental stability and microenvironmental canalization. BMC Evol Biol 10:284

    Article  PubMed  CAS  Google Scholar 

  • Takle H, Baeverfjord G, Lunde M, Kolstad K, Andersen Ø (2005) The effect of heat and cold exposure on HSP70 expression and development of deformities during embryogenesis of Atlantic salmon (Salmo salar). Aquaculture 249:515–524

    Article  CAS  Google Scholar 

  • Tammariello SP, Rinehart JP, Denlinger DL (1999) Desiccation elicits heat shock protein transcription in the flesh fly, Sarcophaga crassipalpis, but does not enhance tolerance to high or low temperatures. J Insect Physiol 45:933–938

    Article  PubMed  CAS  Google Scholar 

  • Tartarotti B, Torres JJ (2009) Sublethal stress: impact of solar UV radiation on protein synthesis in the copepod Acartia tonsa. J Exp Mar Biol Ecol 375:106–113

    Article  PubMed  CAS  Google Scholar 

  • Tedengren M, Olsson B, Bradley B, Zhou LZ (1999) Heavy metal uptake, physiological response and survival of the blue mussel (Mytilus edulis) from marine and brackish waters in relation to the induction of heat-shock protein 70. Hydrobiologia 393:261–269

    Article  CAS  Google Scholar 

  • Thomson RL, Tomás G, Forsman JT, Broggi J, Mönkkönen M (2010) Predator proximity as a stressor in breeding flycatchers: mass loss, stress protein induction, and elevated provisioning. Ecology 91:1832–1840

    Article  PubMed  Google Scholar 

  • Timofeyev MA, Wiegand C, Burnison BK, Shatilina ZM, Pflugmacher S, Steinberg CEW (2004) Impact of natural organic matter (NOM) on freshwater amphipods. Sci Total Environ 319:115–121

    Article  PubMed  CAS  Google Scholar 

  • Timofeyev MA, Shatilina ZM, Protopopova MV, Bedulina DS, Pavlichenko VV, Kolesnichenko AV, Steinberg CEW (2009) Thermal stress defense in freshwater amphipods from contrasting habitats with emphasis on small heat shock proteins (sHSPs). J Therm Biol 34:281–285

    Article  Google Scholar 

  • Timperio AM, Egidi MG, Zolla L (2008) Proteomics applied on plant abiotic stresses: role of heat shock proteins (HSP). J Proteomics 71:391–411

    Article  PubMed  CAS  Google Scholar 

  • Tissières A, Mitchell HK, Tracy UM (1974) Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol 84:389–398

    Article  PubMed  Google Scholar 

  • Todgham AE, Hoaglund EA, Hofmann GE (2007) Is cold the new hot? Elevated ubiquitin-conjugated protein levels in tissues of Antarctic fish as evidence for cold-denaturation of proteins in vivo. J Comp Physiol B 177:857–866

    Article  PubMed  CAS  Google Scholar 

  • Tomanek L (2010) Variation in the heat shock response and its implication for predicting the effect of global climate change on species’ biogeographical distribution ranges and metabolic costs. J Exp Biol 213:971–979

    Article  PubMed  CAS  Google Scholar 

  • Tomanek L, Sanford E (2003) Heat-shock protein 70 (Hsp70) as a biochemical stress indicator: an experimental field test in two congeneric intertidal gastropods (genus: Tegula). Biol Bull 205:276–284

    Article  PubMed  CAS  Google Scholar 

  • Tomanek L, Somero GN (1999) Evolutionary and acclimation-induced variation in the heat-shock responses of congeneric marine snails (genus Tegula) from different thermal habitats: implications for limits of thermotolerance and biogeography. J Exp Biol 202:2925–2936

    PubMed  Google Scholar 

  • Tomás G, Merino S, Martínez S, Moreno J, Sanz JJ (2005) Stress protein levels and blood parasite infection in blue tits (Parus caeruleus): a medication field experiment. Ann Zool Fenn 42:45–56

    Google Scholar 

  • Trautinger F, KindasMugge I, Knobler RM, Honigsmann H (1996) Stress proteins in the cellular response to ultraviolet radiation. J Photochem Photobiol B 35:141–148

    Article  PubMed  CAS  Google Scholar 

  • Vogt RD, Akkanen J, Andersen DO, Brüggemann R, Gjessing E, Kukkonen J, Luster J, Paul A, Pflugmacher S, Starr M, Steinberg CEW, Schmitt-Kopplin P, Zsolnay A (2004) Key site variables governing the functional characteristics of dissolved (DNOM) in Nordic forested catchments. Aquat Sci 66:195–210

    Article  CAS  Google Scholar 

  • Wang D, Liu P, Yang Y, Shen L (2010a) Formation of a combined Ca/Cd toxicity on lifespan of nematode Caenorhabditis elegans. Ecotoxicol Environ Saf 73:1221–1230

    Article  PubMed  CAS  Google Scholar 

  • Wang M, Chan LL, Si M, Hong H, Wang D (2010b) Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR. Toxicol Sci 113:60–69

    Article  PubMed  CAS  Google Scholar 

  • Wang X, Chang L, Sun Z, Zhang Y (2010c) Comparative proteomic analysis of differentially expressed proteins in the earthworm Eisenia fetida during Escherichia coli O157:H7 stress. J Proteome Res 9:6547–6580

    Article  PubMed  CAS  Google Scholar 

  • Wang X, Chang L, Sun Z, Zhang Y (2010d) Analysis of earthworm Eisenia fetida proteomes during cadmium exposure: an ecotoxicoproteomics approach. Proteomics 10:4476–4490

    Article  PubMed  CAS  Google Scholar 

  • Weber LP, Janz DM (2001) Effect of β-naphthoflavone and dimethylbenz[a]anthracene on apoptosis and HSP70 expression in juvenile channel catfish (Ictalurus punctatus) ovary. Aquat Toxicol 54:39–50

    Article  PubMed  CAS  Google Scholar 

  • Werner I, Nagel R (1997) Stress proteins HSP60 and HSP70 in three species of amphipodes exposed to cadmium, diazinon, dieldrin and flouranthene. Environ Toxicol Chem 16:2393–2403

    Article  CAS  Google Scholar 

  • Werner I, Smith TB, Feliciano J, Johnson ML (2005) Heat shock proteins in juvenile steelhead reflect thermal conditions in the Navarro river watershed, California. Trans Am Fish Soc 134:399–410

    Article  CAS  Google Scholar 

  • Wiegand C, Meems N, Timofeyev M, Steinberg CEW, Pflugmacher S (2004) More evidence for humic substances acting as biogeochemicals on organisms. In: Ghabbour EA, Davies G (eds) Humic substances: nature’s most versatile materials. Taylor and Francis, New York, pp 349–363

    Google Scholar 

  • Ziechmann W (1996) Huminstoffe und ihre Wirkungen. Spektrum, Heidelberg

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology Laboratory of Freshwater and Stress Ecology, Humboldt-Universität zu Berlin, Späthstraße 80/81, 12437, Berlin, Germany

    Christian E. W. Steinberg

Authors
  1. Christian E. W. Steinberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christian E. W. Steinberg .

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Steinberg, C.E.W. (2012). Heat Shock Proteins: The Minimal, but Universal, Stress Proteome. In: Stress Ecology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2072-5_5

Download citation

Publish with us

Policies and ethics

Search

Navigation