Skip to main content
SpringerLink
Log in

Status and Impact of Research on Human Pluripotent Stem Cells: Cell Lines and Their Use in Published Research

  • Chapter
  • First Online:
Stem Cells and Cancer Stem Cells, Volume 2

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 2))

  • 1325 Accesses

Abstract

Research on human pluripotent stem cells is rapidly progressing. In the present chapter the current state of research on human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) is analyzed with respect to the number of publicly disclosed cell lines and to the extent and impact of published scientific work involving these cells. Our data reveal that activities in both research fields have markedly increased over the past years and that there are no indications for a diminished role of hESCs in international research as a consequence of the availableness of hiPSCs. Moreover, recent data presented here confirm the global dominance of only a few hESC lines for research, and preferences for distinct hESCs in different countries. Possible causes for these phenomena are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akopian V, Andrews PW, Beil S, Benvenisty N, Brehm J, Christie M, Ford A, Fox V, Gokhale PJ (2010) Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells. In Vitro Cell Dev Biol 46:247–258

    Article  Google Scholar 

  • Aldhous P (2010) The stem cell wars. New Scientist 2764:12–14

    Google Scholar 

  • Alper J (2009) Geron gets green light for human trial of ES cell-derived product. Nat Biotechnol 27:213–214

    Article  PubMed  CAS  Google Scholar 

  • Anon (2011) US approves new trial of embryonic stem cells on blindness. The Independent, 4 Jan 2011, Independent Press Limited, London

    Google Scholar 

  • Ben-Yosef D, Malcov M, Eiges R (2008) PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders. Mol Cell Endocrinol 282:153–158

    Article  PubMed  CAS  Google Scholar 

  • Borstlap J, Stacey G, Kurtz A, Elstner A, Damaschun A, Aran B, Veiga A (2008) First evaluation of the European hESCreg. Nat Biotechnol 26:859–860

    Article  PubMed  CAS  Google Scholar 

  • Borstlap J, Luong MX, Rooke HM, Aran B, Damaschun A, Elstner A, Smith KP, Stein GS, Veiga A (2010) International stem cell registries. In Vitro Cell Dev Biol Anim 46:242–246

    Article  PubMed  Google Scholar 

  • Carvajal-Vergara X, Sevilla A, D’Souza SL, Ang YS, Schaniel C, Lee DF, Yang L, Kaplan AD, Adler ED, Rozov R, Ge Y, Cohen N, Edelmann LJ, Chang B, Waghray A, Su J, Pardo S, Lichtenbelt KD, Tartaglia M, Gelb BD, Lemischka IR (2010) Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465:808–812

    Article  PubMed  CAS  Google Scholar 

  • Connor S (2010) Stem cells could help blind patients to see within six weeks. The Independent, 22 Nov 2011, Independent Press Limited, London

    Google Scholar 

  • Ebert AD, Svendsen CN (2010) Human stem cells and drug screening: opportunities and challenges. Nat Rev Drug Discov 9:367–372

    Article  PubMed  CAS  Google Scholar 

  • Guhr A, Kurtz A, Friedgen K, Löser P (2006) Current state of human embryonic stem cell research: an overview of cell lines and their use in experimental work. Stem Cells 24:2187–2191

    Article  PubMed  Google Scholar 

  • Isasi RM, Knoppers BM (2009) Governing stem cell banks and registries: emerging issues. Stem Cell Res 3:96–105

    Article  PubMed  Google Scholar 

  • Levine AD (2008) Identifying under- and overperforming countries in research related to human embryonic stem cells. Cell Stem Cell 2:521–524

    Article  PubMed  CAS  Google Scholar 

  • Levine AD (2011) Policy uncertainty and the conduct of stem cell research. Cell Stem Cell 8:132–135

    Article  PubMed  CAS  Google Scholar 

  • Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O’Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR (2011) Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 471:68–73

    Google Scholar 

  • Löser P, Guhr A, Kurtz A, Wobus AM (2008) Additional considerations relevant to meta-analyses of hESC publication data. Cell Stem Cell 3:129–130; author reply 131

    Article  PubMed  Google Scholar 

  • Löser P, Schirm J, Guhr A, Wobus AM, Kurtz A (2010) Human embryonic stem cell lines and their use in international research. Stem Cells 28:240–246

    PubMed  Google Scholar 

  • Luong MX, Smith KP, Stein GS (2008) Human embryonic stem cell registries: value, challenges and opportunities. J Cell Biochem 105:625–632

    Article  PubMed  CAS  Google Scholar 

  • McCormick JB, Owen-Smith J, Scott CT (2009) Distribution of human embryonic stem cell lines: who, when, and where. Cell Stem Cell 4:107–110

    Article  PubMed  CAS  Google Scholar 

  • Moretti A, Bellin M, Welling A, Jung CB, Lam JT, Bott-Flugel L, Dorn T, Goedel A, Hohnke C, Hofmann F, Seyfarth M, Sinnecker D, Schomig A, Laugwitz KL (2010) Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med 363:1397–1409

    Article  PubMed  CAS  Google Scholar 

  • MĂĽller FJ, Laurent LC, Kostka D, Ulitsky I, Williams R, Lu C, Park IH, Rao MS, Shamir R, Schwartz PH, Schmidt NO, Loring JF (2008) Regulatory networks define phenotypic classes of human stem cell lines. Nature 455:401–405

    Article  PubMed  Google Scholar 

  • MĂĽller FJ, Goldmann J, Löser P, Loring JF (2010) A call to standardize teratoma assays used to define human pluripotent cell lines. Cell Stem Cell 6:412–414

    Article  PubMed  Google Scholar 

  • Owen-Smith J, McCormick J (2006) An international gap in human ES cell research. Nat Biotechnol 24:391–392

    Article  PubMed  CAS  Google Scholar 

  • Saha K, Hurlbut JB (2011) Disease modeling using pluripotent stem cells: making sense of disease from bench to bedside. Swiss Med Wkly 141:w13144

    PubMed  Google Scholar 

  • Scott CT, McCormick JB, Owen-Smith J (2009) And then there were two: use of hESC lines. Nat Biotechnol 27:696–697

    Article  PubMed  CAS  Google Scholar 

  • Scott CT, McCormick JB, Derouen MC, Owen-Smith J (2010) Federal policy and the use of pluripotent stem cells. Nat Methods 7:866–867

    Article  PubMed  CAS  Google Scholar 

  • Sermon KD, Simon C, Braude P, Viville S, Borstlap J, Veiga A (2009) Creation of a registry for human embryonic stem cells carrying an inherited defect: joint collaboration between ESHRE and hESCreg. Hum Reprod 24:1556–1560

    Article  PubMed  CAS  Google Scholar 

  • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861–872

    Article  PubMed  CAS  Google Scholar 

  • Taymor K, Scott CT (2009) The practical consequences of a national human embryonic stem cell registry. Stem Cell Rev 5:315–318

    Article  PubMed  Google Scholar 

  • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM (1998) Embryonic stem cell lines derived from human blastocysts. Science 282:1145–1147

    Article  PubMed  CAS  Google Scholar 

  • Wobus AM, Löser P (2011) Present state and future perspectives of using pluripotent stem cells in toxicology research. Arch Toxicol 85:79–117

    Article  PubMed  CAS  Google Scholar 

  • Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917–1920

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Roberts Koch Institute, DGZ-Ring1, D-13086, Berlin, Germany

    Peter Löser, Anke Guhr & Sabine Kobold

  2. Leibniz Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany

    Anna M. Wobus

  3. Berlin Brandeburg Center for Regenerative Therapies, Berlin, Germany

    Andreas Kurtz

  4. Seoul National University, Seoul, Korea

    Andreas Kurtz

Authors
  1. Peter Löser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anke Guhr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sabine Kobold
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anna M. Wobus
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Andreas Kurtz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter Löser .

Editor information

Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Löser, P., Guhr, A., Kobold, S., Wobus, A.M., Kurtz, A. (2012). Status and Impact of Research on Human Pluripotent Stem Cells: Cell Lines and Their Use in Published Research. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2016-9_7

Download citation

Publish with us

Policies and ethics

Search

Navigation