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Stem Cells and Cancer Stem Cells, Volume 2 pp 291–298Cite as

Human Embryonic Stem Cells Transplanted into Mouse Retina Induces Neural Differentiation

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 2))

Abstract

Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells can be transplanted and integrated into the retinas of adult mice as well-differentiated retinal cells. Thus these cells have the potential to be used to repair or regenerate diseased retina as cell replacement therapy in the future. The major concern with the possible transplantation of human ES (hES) or iPS cells in retinal diseases is, however, their ability to form tumors including mature and immature teratoma. In this review, we discuss the differentiation to retinal cells, including photoreceptor cells, and ganglion cells from hES or iPS cells transplanted into mouse retina. We also discuss possible strategies to overcome the major concern of potential teratoma formation and improve cell integration into host retina. Finally, we consider the future retinal cell therapy that may be used as a therapeutic strategy to treat retinal diseases.

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Author information

Authors and Affiliations

  1. Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Akira Hara, Manabu Takamatsu, Yuichiro Hatano, Hiroyuki Tomita & Toshiya Kuno

  2. Department of Tissue and Organ Development, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Hitomi Aoki & Takahiro Kunisada

  3. Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan

    Masayuki Niwa

Authors
  1. Akira Hara
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  2. Hitomi Aoki
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  3. Manabu Takamatsu
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  4. Yuichiro Hatano
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  5. Hiroyuki Tomita
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  6. Toshiya Kuno
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  7. Masayuki Niwa
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  8. Takahiro Kunisada
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Corresponding author

Correspondence to Akira Hara .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Hara, A. et al. (2012). Human Embryonic Stem Cells Transplanted into Mouse Retina Induces Neural Differentiation. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2016-9_31

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