Abstract
Therapies using stem cells and tissue engineering for cardiovascular regeneration aim to repair damaged cardiac tissue by delivering stem cells with biomaterials and biomolecules to support cell survival and differentiation. When implanted in undifferentiated states, stem cells recognize the cues around them to adopt a variety of cell fates. However, disease processes (e.g., myocardial infarcts) alter the microenvironment, and differentiation is often misdirected. For this reason it is best to differentiate stem cells into cardiomyocyte specific lineages in vitro prior to implantation. Stem cells can form mature cardiac muscle cells by employing various differentiation methods, including epigenetic modification, differentiation media, and co-culture with neonatal cardiomyocytes. Here we discuss adipose tissue-derived stem cells and how they may be directed into cardiomyocytes for tissue engineering.
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Dilley, R., Choi, Y.S., Dusting, G. (2012). Generating Human Cardiac Muscle Cells from Adipose-Derived Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2016-9_28
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DOI: https://doi.org/10.1007/978-94-007-2016-9_28
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