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Treatment of Heart Disease: Use of Transdifferentiation Methodology for Reprogramming Adult Stem Cells

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Stem Cells and Cancer Stem Cells, Volume 2

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 2))

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Abstract

Despite significant progress in medical research, cardiovascular diseases (CVDs) continue to be the largest contributors to morbidity and mortality in both developed and developing countries. The discovery of multipotent cell populations in adult tissues has opened up new therapeutic possibilities for diseases that cannot be successfully treated by conventional medical therapies. The scientific community is developing new methods to improve clinical outcomes, including the transplantation of stem cells in a pre-differentiated state. In vivo studies have demonstrated the capacity of these cells to differentiate into another cell type through the triggering of a genetic switch by pathological or inductive conditions. This process, whereby one cell type committed to and progressing along a specific developmental lineage switches into another cell type of a different lineage, is designated transdifferentiation and takes place in tissues generated from neighbouring regions during normal embryonic development. In this chapter, we review the current methods of transdifferentiation including guided cardiopoiesis, cellular extracts, co-culture techniques, viral vectors, hyperpolarization, among others.

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Author information

Authors and Affiliations

  1. Biopathology and Medicine Regenerative Institute (IBIMER), Granada, Spain

    Milán Bustamante

  2. Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain

    Juan Antonio Marchal & Fernando Rodríguez-Serrano

  3. Biopathology and Medicine Regenerative Institute (IBIMER), FIBAO, University of Granada, 18012, Granada, Spain

    Pablo Álvarez

  4. Biopathology and Medicine Regenerative Institute (IBIMER), Granada, Spain

    Antonia Aránega

  5. Biopathology and Medicine Regenerative Institute FIBAO (IBIMER), Granada, Spain

    Macarena Perán

Authors
  1. Milán Bustamante
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  2. Macarena Perán
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  3. Juan Antonio Marchal
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  4. Fernando Rodríguez-Serrano
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  5. Pablo Álvarez
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  6. Antonia Aránega
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Corresponding author

Correspondence to Antonia Aránega .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Bustamante, M., Perán, M., Marchal, J.A., Rodríguez-Serrano, F., Álvarez, P., Aránega, A. (2012). Treatment of Heart Disease: Use of Transdifferentiation Methodology for Reprogramming Adult Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2016-9_18

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