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Cytokines, Heart and Calcium Current in Sepsis

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Mechanical Stretch and Cytokines

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 5))

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Abstract

Sepsis has been defined as the systemic host response to infection with an overwhelming systemic production of cytokines leading to generalized endothelial and epithelial damages, to the changes in immune and neuroendocrine systems and consequently to (multiple) organ dysfunction. The myocardial contractile performance is significantly impaired in severe sepsis and septic shock. In this review the major cytokines involved in the development of sepsis are characterized with special emphasis on cardiac function and on regulation of cardiac calcium current.

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Acknowledgement

This work was supported by the Research Project MSM 0021620819 (Replacement of and support to some vital organs).

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine in Plzen, Charles University in Prague, 301 66, Plzen, Czech Republic

    Milan Stengl

  2. Department of Clinical Biochemistry, Hematology and Immunology, Na Homolce Hospital, Prague, Czech Republic

    Miroslav Prucha

  3. 1st Medical Department, Faculty of Medicine in Plzen, University Hospital Plzen, Charles University in Prague, Plzen, Czech Republic

    Martin Matejovic

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  1. Milan Stengl
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  2. Miroslav Prucha
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  3. Martin Matejovic
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Correspondence to Milan Stengl .

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Editors and Affiliations

  1. Dept. Fundamental &, Applied Physiology, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Andre Kamkin

  2. , Department of Fundamental and Applied Ph, Russian State Medical University, Ostrovitjanova Str. 1, Moscow, 117997, Russian Federation

    Irina Kiseleva

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Stengl, M., Prucha, M., Matejovic, M. (2012). Cytokines, Heart and Calcium Current in Sepsis. In: Kamkin, A., Kiseleva, I. (eds) Mechanical Stretch and Cytokines. Mechanosensitivity in Cells and Tissues, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2004-6_4

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