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Evidence-based Anticancer Materia Medica for Cervical Cancer

  • Tatjana Stanojković
  • Aleksandra Konić-Ristić
  • Teodora Janković
  • Gordana Zdunić
  • Katarina Šavikin
Chapter
Part of the Evidence-based Anticancer Complementary and Alternative Medicine book series (ACAM, volume 2)

Abstract

Carcinoma of the cervix is the second most common malignant neoplasia among women, following breast cancer. Approximately 500,000 new cases of cervix cancer are diagnosed worldwide each year. Along with conventional chemotherapeutic or surgery treatment, there is an increased interest in alternative treatment modalities that include complementary and alternative medicine (CAM). In this chapter, we have reviewed the literature related with the herbs, herbal formulations and phytochemical constituents that act specifically inhibiting the neoplasia of the cervix. Large amount of data is available on in vitro anticancer effects of different herbal preparations and isolated bioactive compounds on cervical cancer cells, evaluating the mechanisms that underlie their effects. Turmeric, mistletoe and green tea are representative plants that exert anticancer effects. Despite of large amount of data on in vitro anticancer effects of different herbal preparations and isolated bioactive compounds on cervical cancer cells, only few clinical studies have been performed in humans. Only paclitaxel, irinotecan, and vinorelbine (chemotherapeutic agents of plant origin) have been investigated in an ongoing a Phase III clinical trials or already successfully applied as a part of conventional chemotherapeutic regiments for cervical cancer. The continued popularity of herbal remedies worldwide suggests that evidence-based research in this field, as well as information regarding the potential efficacy and safety of phytochemical constituents in herbs is essential, particularly when CAM is used in combination with other drugs.

Keywords

Cervical Cancer Cervical Intraepithelial Neoplasia Cervical Cancer Cell Ursolic Acid Curcuma Longa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

The authors acknowledge the gratitude to the Ministry of Science and Technological Development of Serbia for financial support, project No. 46013.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Tatjana Stanojković
    • 1
  • Aleksandra Konić-Ristić
    • 2
  • Teodora Janković
    • 3
  • Gordana Zdunić
    • 3
  • Katarina Šavikin
    • 3
  1. 1.Institute of Oncology and Radiology of SerbiaBelgradeSerbia
  2. 2.Department of Nutrition and MetabolismInstitute for Medical ResearchBelgradeSerbia
  3. 3.Institute for Medicinal Plants ResearchBelgradeSerbia

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