Abstract
The purpose of this work was the analysis of the effects of bystander factors from blood sera of people affected by the Chernobyl accident on human keratinocyte cell culture (HPV-G cells). A new method was developed for evaluation of bystander factor presence in vivo in blood of people irradiated by the Chernobyl accident. Affected population groups included liquidators of the Chernobyl accident and people living and working in areas of Gomel region contaminated by radionuclides. The analysis has shown that bystander factors persist in Chernobyl liquidator blood samples for more than 20 years since irradiation. The data suggest that blood sera contain bystander factors, which are able to induce micronuclei and decrease metabolic activity of HPV-G cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
Polessky State Radiation and Environment Reserve (founded in 1988) is a territory of Gomel region, where humans cannot live because of the very high levels of radiation contamination. The territory of this reservation is 215.5 ha.
References
Baverstock K, Belyakov OV (2010) Some important questions connected with non-targeted effects. Mutat Res 687:84–88
Emerit I (1990) Superoxide production by clastogenic factors. In: Crastes de Paulet A, Douste-Blazy L, Paoletti R (eds) Free radicals, lipoproteins and membrane lipids. Plenum Press, New York, pp 99–104
Emerit I, Cernjavski L, Arutyunyan R, Oganesian N, Pogosian H, Mejlumian H, Sarkisian T, Gulkandanian M, Quastel M, Goldsmith J, Riklis E, Kordysh R, Poliak S, Merklin L (1994) Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor. J Cancer Res Clin Oncol 120:558–561
Emerit I, Oganesian N, Sarkisian T, Arutyunyan R, Pogosian A, Asrian K, Levy A, Cernjavski L (1995) Clastogenic factors in the plasma of Chernobyl accident recovery workers. Anticlastogenic effect of Ginkgo biloba extract. Radiat Res 144:198–205
Emerit I, Oganesian N, Arutyunyan R, Pogossian A, Sarkisian T, Cernjavski L, Levy A, Feingold J (1997) Oxidative stress-related clastogenic factors in plasma from Chernobyl liquidators: protective effects of antioxidant plant phenols, vitamins and ligoelements. Mutat Res 377:239–246
Mosse I, Marozik P, Seymour C, Mothersill C (2006) The effect of melanin on the bystander effect in human keratinocytes. Mutat Res 597:133–137
Mothersill C, Seymour C (1997) Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int J Radiat Biol 71:421–427
Nagasawa H, Little JB (1992) Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res 52:6394–6396
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media B.V.
About this paper
Cite this paper
Marozik, P.M., Mosse, I.B., Melnov, S.B., Marozik, M.S., Mothersill, C.E., Seymour, C.B. (2012). Effects of Bystander Factors Induced In Vivo in Blood of People Affected by Chernobyl Accident. In: Mothersill, C., Korogodina, V., Seymour, C. (eds) Radiobiology and Environmental Security. NATO Science for Peace and Security Series C: Environmental Security. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1939-2_16
Download citation
DOI: https://doi.org/10.1007/978-94-007-1939-2_16
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-1938-5
Online ISBN: 978-94-007-1939-2
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)