Skip to main content
SpringerLink
Log in

Extraaxial Brain Tumors: The Role of Genetic Polymorphisms

  • Chapter
  • First Online:
Tumors of the Central Nervous System, Volume 4

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 4))

  • 1691 Accesses

Abstract

Extraaxial tumors of the nervous system are extra-cerebral and often benign. Meningiomas, schwannomas and metastasis are the part of this group. The onset of a tumor occurs from the accumulation of genetic and epigenetic alterations in cells. To understand the molecular mechanism of tumor progression and metastasis formation is essential to identify the genes that accumulate these alterations. This study aimed at evaluating, through a case-control study, the influence of SNPs TP53 Pro47Ser and Arg72Pro, EGF + 61 and GSTP-1 Ile105Val on the development and prognosis of these tumors. Through the analysis of the polymorphisms Pro47Ser and Arg72Pro of the gene TP53, it was noticed that the polymorphic variant Ser47 is strongly associated with patients with extraaxial tumors and the presence of the variants Ser47 and Pro72 increase the risk of these tumors. Regarding the gene GSTP-1, it was concluded that the Val105 allele was more frequent among subjects with cancer and the presence of this allele in the population studied increased the risk of cancer in almost 6-fold. Finally, it was observed that the frequency of wild genotype G/G of the polymorphism EGF + 61 was higher among patients (particularly among those with low grade tumors) than among the control group and the presence of this allele may influence the risk of developing meningiomas, schwannomas and metastases in the subjects studied.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Araujo A, Ribeiro R, Azevedo I, Coelho A, Soares M, Sousa B, Pinto D, Lopes C, Medeiros R, Scagliotti GV (2007) Genetic polymorphisms of the epidermal growth factor and related receptor in non-small cell lung cancer – a review of the literature. Oncologist 12:201–210

    Article  PubMed  CAS  Google Scholar 

  • Biros E, Kalina I, Kohut A, Bogyiova E, Salagovic J, Sulla I (2002) Allelic and haplotype frequencies of the p53 polymorphisms in brain tumor patients. Physiol Res 51:59–64

    PubMed  CAS  Google Scholar 

  • Chen AM, Jahan TM, Jablons DM, Garcia J, Larson DA (2007) Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain. Cancer 109:1668–1675

    Article  PubMed  Google Scholar 

  • Costa BM, Ferreira P, Costa S, Canedo P, Oliveira P, Silva A, Pardal F, Suriano G, Machado JC, Lopes JM, Reis RM (2007) Association between functional EGF + 61 polymorphism and glioma risk. Clin Cancer Res 13:2621–2626

    Article  PubMed  CAS  Google Scholar 

  • De Roos AJ, Rothman N, Inskip PD, Linet MS, Shapiro WR, Selker RG, Fine HA, Black PM, Pittman GS, Bell DA (2003) Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev 12:14–22

    PubMed  Google Scholar 

  • Drevelegas A (2005) Extra-axial brain tumors. Eur Radiol 15:453–467

    Article  PubMed  Google Scholar 

  • Felley-Bosco E, Weston A, Cawley HM, Bennett WP, Harris CC (1993) Functional studies of a germ-line polymorphism at codon 47 within the p53 gene. Am J Hum Genet 53:752–759

    PubMed  CAS  Google Scholar 

  • Hadhri-Guiga B, Toumi N, Khabir A, Sellami-Boudawara T, Ghorbel A, Daoud J, Frikha M, Gargouri A, Mokdad-Gargouri R (2007) Proline homozygosity in codon 72 of TP53 is a factor of susceptibility to nasopharyngeal carcinoma in Tunisia. Cancer Genet Cytogenet 178:89–93

    Article  PubMed  CAS  Google Scholar 

  • Hanemann CO, Evans DG (2006) News on the genetics, epidemiology, medical care and translational research of Schwannomas. J Neurol 253:1533–1541

    Article  PubMed  CAS  Google Scholar 

  • Harari PM, Allen GW, Bonner JA (2007) Biology of interactions: antiepidermal growth factor receptor agents. J Clin Oncol 25:4057–4065

    Article  PubMed  CAS  Google Scholar 

  • Idbaih A, Boisselier B, Marie Y, El Hallani S, Sanson M, Criniere E, Rodero M, Carpentier C, Paris S, Laigle-Donadey F, Ducray F, Hoang-Xuan K, Delattre JY (2007) TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors. Cancer Genet Cytogenet 177:103–107

    Article  PubMed  CAS  Google Scholar 

  • Leite JL, Manfrinatto JA, Mazzali M, Ward LS (2006) Polymorphisms at exon 4 of p53 and the susceptibility to herpesvirus types 6 and 1 infection in renal transplant recipients. Transpl Int 19:732–737

    Article  PubMed  CAS  Google Scholar 

  • Li X, Dumont P, Della Pietra A, Shetler C, Murphy ME (2005) The codon 47 polymorphism in p53 is functionally significant. J Biol Chem 280:24245–24251

    Article  PubMed  CAS  Google Scholar 

  • Lusis E, Gutmann DH (2004) Meningioma: an update. Curr Opin Neurol 17:687–692

    Article  PubMed  Google Scholar 

  • Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E, Vecht C (2008) Meningioma. Crit Rev Oncol Hematol 67:153–171

    Article  PubMed  Google Scholar 

  • Moyer AM, Salavaggione OE, Wu TY, Moon I, Eckloff BW, Hildebrandt MA, Schaid DJ, Wieben ED, Weinshilboum RM (2008) Glutathione s-transferase p1: gene sequence variation and functional genomic studies. Cancer Res 68:4791–4801

    Article  PubMed  CAS  Google Scholar 

  • Ohgaki H, Kleihues P (2005) Epidemiology and etiology of gliomas. Acta Neuropathol 109:93–108

    Article  PubMed  Google Scholar 

  • Pinto GR, Yoshioka FK, Clara CA, Santos MJ, Almeida JR, Burbano RR, Rey JA, Casartelli C (2008) WRN Cys1367Arg SNP is not associated with risk and prognosis of gliomas in Southeast Brazil. J Neurooncol 90:253–258

    Article  PubMed  CAS  Google Scholar 

  • Puttonen S, Keltikangas-Jarvinen L, Elovainio M, Kivimaki M, Rontu R, Lehtimaki T (2007) Temperamental activity and epidermal growth factor A61G polymorphism in Finnish adults. Neuropsychobiology 56:208–212

    Article  PubMed  CAS  Google Scholar 

  • Rufini V, Salvatori M, Fadda G, Pinnarelli L, Castaldi P, Maussier ML, Galli G (2007) Thyroid carcinomas with a variable insular component: prognostic significance of histopathologic patterns. Cancer 110:1209–1217

    Article  PubMed  Google Scholar 

  • Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, Wolf CR, Ogreid D, Ulvik A, Vu P, Haugen A (1997) Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk. Carcinogenesis 18:1285–1289

    Article  PubMed  CAS  Google Scholar 

  • Sachidanandam R, Weissman D, Schmidt SC, Kakol JM, Stein LD, Marth G, Sherry S, Mullikin JC, Mortimore BJ, Willey DL, Hunt SE, Cole CG, Coggill PC, Rice CM, Ning Z, Rogers J, Bentley DR, Kwok PY, Mardis ER, Yeh RT, Schultz B, Cook L, Davenport R, Dante M, Fulton L, Hillier L, Waterston RH, Mcpherson JD, Gilman B, Schaffner S, Van Etten WJ, Reich D, Higgins J, Daly MJ, Blumenstiel B, Baldwin J, Stange-Thomann N, Zody MC, Linton L, Lander ES, Altshuler D (2001) A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409:928–933

    Article  PubMed  CAS  Google Scholar 

  • Schwartzbaum JA, Ahlbom A, Lonn S, Warholm M, Rannug A, Auvinen A, Christensen HC, Henriksson R, Johansen C, Lindholm C, Malmer B, Salminen T, Schoemaker MJ, Swerdlow AJ, Feychting M (2007) An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. Cancer Epidemiol Biomarkers Prev 16:559–565

    Article  PubMed  CAS  Google Scholar 

  • Shahbazi M, Pravica V, Nasreen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osborne JE, Lear JT, Smith AG, Hutchinson IV (2002) Association between functional polymorphism in EGF gene and malignant melanoma. Lancet 359:397–401

    Article  PubMed  CAS  Google Scholar 

  • Smigielski EM, Sirotkin K, Ward M, Sherry ST (2000) dbSNP: a database of single nucleotide polymorphisms. Nucleic Acids Res 28:352–355

    Article  PubMed  CAS  Google Scholar 

  • Stafford LJ, Vaidya KS, Welch DR (2008) Metastasis suppressors genes in cancer. Int J Biochem Cell Biol 40:874–891

    Article  PubMed  CAS  Google Scholar 

  • Suh Y, Vijg J (2005) SNP discovery in associating genetic variation with human disease phenotypes. Mutat Res 573:41–53

    PubMed  CAS  Google Scholar 

  • Vauleon E, Auger N, Amiel AB, Donadey FL, Kaloshi G, Lejeune J, Delattre JY, Thillet J, Sanson M (2007) The 61 A/G EGF polymorphism is functional but is neither a prognostic marker nor a risk factor for glioblastoma. Cancer Genet Cytogenet 172:33–37

    Article  PubMed  CAS  Google Scholar 

  • Wang Y, Tian T, Hu Z, Tang J, Wang S, Wang X, Qin J, Huo X, Gao J, Ke Q, Jin G, Ma H, Wang X, Shen H (2008) EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women. Breast Cancer Res Treat 111:321–327

    Article  PubMed  CAS  Google Scholar 

  • Wrobel G, Roerig P, Kokocinski F, Neben K, Hahn M, Reifenberger G, Lichter P (2005) Microarray-based gene expression profiling of benign, atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression. Int J Cancer 114:249–256

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oncogenetic Laboratory, Department of Medical Genetics, Rebeirao Preto Medical School, University of Sao Paulo, 14049-900, Ribeirao Preto, SP, Brazil

    Luciana Oliveira de Almeida

Authors
  1. Luciana Oliveira de Almeida
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Luciana Oliveira de Almeida .

Editor information

Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

de Almeida, L.O. (2012). Extraaxial Brain Tumors: The Role of Genetic Polymorphisms. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 4. Tumors of the Central Nervous System, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1706-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-1706-0_6

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-1705-3

  • Online ISBN: 978-94-007-1706-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation