Abstract
Genome and transcriptome analysis of desmoid-type fibromatosis (DTF) and scar tissue with DNA microarray and high-throughput sequencing (HTS) has yielded abundant data. Given the similar histologic appearance of normal scars, keloids, and DTF, and yet markedly dissimilar invasive and recurrent nature of DTF, it is critical to elucidate the underlying biologic differences contributing to the aggressiveness of DTF. Multiple gene sets and biologic pathways have been found to be enriched in DTF when compared with other noninvasive fibroblastic lesions. Investigation is required to fully characterize the pathogenesis with the hope of identifying novel diagnostic markers and therapeutic targets.
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Sweeney, R.T., van de Rijn, M. (2012). Microarrays and High-Throughput Sequencing in Desmoid-Type Fibromatosis and Scar. In: Litchman, C. (eds) Desmoid Tumors. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1685-8_12
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DOI: https://doi.org/10.1007/978-94-007-1685-8_12
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