Preventing Malformations

  • Harold Kalter


Soon after the beginning of the insulin era it became a firm tenet that the infants of pregnant diabetic women were at increased risk of congenital malformations. Addressing this consensus the causes and prevention of these abnormalities were the subject of countless scholarly publications. From early on innumerable etiological factors—genetic, metabolic, teratologic—were considered as the possible basis of this risk (e.g. Gabbe 1977; Simpson 1978). But for prevention the most promising path to pursue seemed the metabolic one, since as was reasoned, “if perturbations in the maternal metabolic milieu¼cause anomalies in offspring, then strict diabetic control should lower the anomaly rates¼” (Ober and Simpson 1986)


Congenital Malformation Diabetic Woman Diabetic Mother Preconception Care Diabetic Pregnancy 
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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.RockvilleUSA

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