Drugs Affecting Mast Cells

  • Domenico Ribatti
  • Enrico Crivellato


Preliminary studies using anti-KIT antibodies (Huang et al. 2008), anti-TNF-α antibodies (Gounaris et al. 2007) or the MC stabilizer disodium cromoglycate (cromolyn) (Soucek et al. 2007) in mouse models demonstrated promising results even if administered after the initiation of tumour development. Treatment of mice bearing mammary adenocarinoma and pancreatic cancer with cromolyn led to clotting of blood vessels, hypoxia and tumour cell apoptosis (Samoszuk and Corwin 2003a, b; Soucek et al. 2007). Unfortunately, cromolyn is a weak inhibitor of human MC secretion and is poorly adsorbed, so it is unlikely to be effective in treating cancer in humans.


Imatinib Mesylate Tumour Cell Apoptosis Medicinal Leech Disodium Cromoglycate Bone Marrow Angiogenesis 
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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of Human Anatomy and HistologyUniversity of Bari Medical School PoliclinicoBariItaly
  2. 2.Section of Anatomy Department of Experimental and Clinical MedicineUniversity of Udine Medical SchoolUdineItaly

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