Concluding Remarks and Perspectives

  • Domenico Ribatti
  • Enrico Crivellato


As depicted in this survey, MCs represent a class of phylogenetically old cells which are implicated in a broad spectrum of tissue reactions, ranging from inflammation to healing responses. The roles of these cells in normal physiology and in the pathogenesis of several human diseases in addition to allergic reactions have been the subject of increasing interest. As a matter of fact, MCs are now regarded as effective elements in many physiopathological conditions and actively contribute to functional networks leading to specific disease conditions. For many decades their involvement in tumour biology has largely been recognized. Presently, a great bulk of experimental and clinical investigations allows us to think over the complex interaction between MCs and tumours. Most studies reported a positive correlation between the number of MCs and the clinical prognosis in various human tumour types.


Tumour Microenvironment Treg Cell Chondroitin Sulfate Great Bulk Effective Element 
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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of Human Anatomy and HistologyUniversity of Bari Medical School PoliclinicoBariItaly
  2. 2.Section of Anatomy Department of Experimental and Clinical MedicineUniversity of Udine Medical SchoolUdineItaly

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