• Domenico Ribatti
  • Enrico Crivellato


The mast cell (MC) is a type of bone marrow-derived, tissue-homing secretory cell, which was identified by Paul Ehrlich in 1878 and first described in his doctoral thesis. In normal histological sections, the MC shows a very characteristic picture which consists in an abundant cytoplasm filled with thousands of granules. It is a ubiquitous cell which populates the connective tissues of the different organs and locates in particular to the lying surfaces of the body, such as the skin and the gastrointestinal and respiratory tracts. Inner sites, however, as the central nervous system, are also populated by MCs.


Mast Cell Aortic Aneurysm Coronary Spasm Abundant Cytoplasm Stimulate Tumour Growth 
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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of Human Anatomy and HistologyUniversity of Bari Medical School PoliclinicoBariItaly
  2. 2.Section of Anatomy Department of Experimental and Clinical MedicineUniversity of Udine Medical SchoolUdineItaly

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