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Luminescent Porous Silicon Nanoparticles as Drug Carrier

  • Vera La Ferrara
  • Girolamo Di Francia
  • Giuseppe Fiorentino
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 91)

Abstract

In this work, the applicability of luminescent porous silicon (PS) nanoparticles as ascorbic acid (AA) carrier has been studied. PS nanoparticles have been realized reducing in multi-sized particles porous silicon free-standing film placed in deionized water by sonication and filtering through 0.45 ?m membrane. The PS nanoparticles are water-soluble and highly fluorescent. PS nanoparticles are loaded by AA, monitoring the fluorescence spectra by a spectrofluorimeter. Before assessing the loading of AA into PS nanoparticles dispersed in water, the emission stability of PS solution has been acquired. Once stabilized the signal and loaded the AA, the presence and the real absorption of AA onto PS nanoparticles has been evaluated from emission quenching of the silicon nanoparticles.

Keywords

Ascorbic Acid Porous Silicon Emission Stability Efficient Drug Loading Porous Silicon Film 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

The authors gratefully acknowledge the Ministry of Universities and Research (MIUR) for financial support as part of Public-Private Laboratory TRIPODE (Technologies and Research for the application of polymers in electronics devices).

References

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    Park J-H, Gu L, von Maltzahn G, Ruoslahti E, Bhatia SN, Sailor MJ (2009) Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mat 8:331–336CrossRefGoogle Scholar
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    Parka HW, Alama SM, Leea SH, Karima MM, Wabaidura SM, Kangb M, Choi JH (2009) Optical ascorbic acid sensor based on fluorescence quenching of Ag nanoparticles. Luminescence 24:367–371Google Scholar
  3. 3.
    Halimaoui A (1997) Porous silicon formation by anodisation. In: Cahnam L (ed) Properties of porous silicon, pp 12–22, ISBN 0852969325Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Vera La Ferrara
    • 1
  • Girolamo Di Francia
    • 1
  • Giuseppe Fiorentino
    • 2
  1. 1.ENEA Research CenterPorticiItaly
  2. 2.Department of PhysicsUniversity “Federico II”NaplesItaly

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