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Electrospinning and Tissue Engineering

  • Geoffrey R. Mitchell
  • Fred Davis
Chapter
Part of the Computational Methods in Applied Sciences book series (COMPUTMETHODS, volume 20)

Abstract

We review how the process of generating scaffolds for tissue engineering using the process of electrospinning sits alongside other more established pro cedures for the preparation of scaffolds. We identify the key potential advantages of electrospinning for constructing scaffolds and we explore some of the remaining challenges. Several of these focus on the solvent and the desirability of using water for biological systems rather than highly volatile solvents such as those based on fluoroalcohols which lead, for example to the denaturing of collagen. We show how the control of temperature opens several opportunities as does the inclusion of additives to influence conductivity and viscosity. We show how the use of alternative electrode arrangements can lead to a control of the internal organisation with potential for property enhancement. It is reasonable to currently see electrospinning as an area dominated by experimental work but there is a growing computational element and we review how far such developments have reached and the potential for identifying new solutions for the application of electrospinning to tissue engineering.

Keywords

Tissue Engineering Tangential Velocity Tissue Engineer Electrospun Fibre Electrospinning Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media 2011

Authors and Affiliations

  1. 1.University of ReadingReadingUK
  2. 2.Centre for Rapid and. Sustainable Product DevelopmentPolytechnic Institute of LeiriaLeiriaPortugal

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