Geometric modeling and analysis of bone micro–structures as a base for scaffold design

  • Y. Holdstein
  • L. Podshivalov
  • A. Fischer
Part of the Computational Methods in Applied Sciences book series (COMPUTMETHODS, volume 20)


Bones consist of hierarchical bio-composite materials arranged in multi scale structural geometry. This structure is vulnerable to various damaging factors that may cause its degradation, such as accidents, medical operations and diseases. Imaging techniques can already provide highly detailed micro-features of a bone or even its complete volumetric micro-structure. A three-dimensional model of the bone can then be reconstructed and analyzed. However, current technology cannot precisely fix damaged bone tissue and can only roughly approximate such damaged structures by using scaffolds with standard geometry. This paper proposes a new method for creating natural scaffolds that can adapt according to location, size and shape. The method is based on constructing the scaffold as a 3D volumetric texture that imitates the irregular textural behavior of its surroundings. The method has the ability to create a smooth and continuous structure according to topological and geometrical characteristics. Moreover, the texture captures the stochastic and porous nature of the bone micro-structure. The resulting scaffold texture is tested by applying mechanical analysis to the new synthesized structure, thus controlling the mechanical properties of the reconstructed bone. We believe our method will help in customizing the design and fabrication of scaffolds for bone micro structures. Moreover, such scaffolds can facilitate the process of rehabilitating damaged bone.


Bone Model Hexahedral Element Texture Synthesis Healthy Bone Structure Model Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media 2011

Authors and Affiliations

  1. 1.Faculty of Mechanical EngineeringTechnion – Israel Institute of TechnologyHaifaIsrael

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