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Electrochemical Detection of DNA Using Nanomaterials Based Sensors

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Detection of Non-Amplified Genomic DNA

Part of the book series: Soft and Biological Matter ((SOBIMA))

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Abstract

The detection of non-amplified DNA sequences plays a crucial role in the rapid diagnosis of genetic-related diseases especially for early stage treatment. Among the various biosensors that have been used for DNA detection, electrochemical sensors show great promise because they present efficient signal transduction and are capable of precise DNA recognition at a relatively low cost in addition to the broad range of designs with interest to be applied in different kinds of samples. Advancements in micro- and nanotechnologies, specifically fabrication techniques and new nanomaterials, have enabled for the development of highly sensitive, highly specific electrochemical sensors making them attractive for the detection of small sequence variations. Furthermore, the integration of sensors with sample preparation and fluidic processes enables for rapid, multiplexed electrochemical DNA detection essential for point of care clinical diagnostics.

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Acknowledgments

We acknowledge funding from MICINN (Madrid) for the projects MAT2008-03079 and MAT2011-25870.

Author information

Authors and Affiliations

  1. Institut Català de Nanotecnologia, Nanobioelectronics and Biosensors Group, CIN2 (ICN-CSIC), Barcelona, Spain

    Sergio Marín & Arben Merkoçi

Authors
  1. Sergio Marín
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  2. Arben Merkoçi
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Correspondence to Arben Merkoçi .

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Editors and Affiliations

  1. , Department of Chemical Science, University of Catania, Viale Andrea Doria 6, Catania, 95125, Italy

    Giuseppe Spoto

  2. , Faculty of Science, University of Parma, Parma, 43100, Italy

    Roberto Corradini

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Marín, S., Merkoçi, A. (2012). Electrochemical Detection of DNA Using Nanomaterials Based Sensors. In: Spoto, G., Corradini, R. (eds) Detection of Non-Amplified Genomic DNA. Soft and Biological Matter. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1226-3_7

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