Other Multifactorial Disorders for Which Genetic/Genomic Testing Is Providing Insights

Chapter

Abstract

This chapter describes the progress that has been made in personalizing medicine in several fields other than cancer and cardiovascular disease. A brief review is given of the gene variants that help predict, diagnose and treat age-related macular degeneration, type 2 diabetes mellitus, psychiatric disorders, substance abuse, Alzheimer disease and age-related cognitive decline, asthma and other respiratory disorders. The chapter discusses the clinically useful tests that have already been developed, several promising early discoveries that must now be reevaluated, and a number of basic research discoveries that will provide the basis for developing clinically useful tests in the near future.

Keywords

Alzheimer Disease COMT Gene Prefrontal Lobe Nongenetic Factor COMT Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Readings

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  5. Rubinsztein DC, Easton DF (1999) Apolipoprotein E genetic variation and Alzheimer’s disease. A meta-analysis. Dement Geriatr Cogn Disord May-Jun;10(3):199 –209PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Clinical Cancer Genetics and Medical GeneticsThe Ohio State UniversityColumbusUSA
  2. 2.Biology DepartmentWestern Carolina UniversityCullowheeUSA

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