Other Multifactorial Disorders for Which Genetic/Genomic Testing Is Providing Insights

  • Kevin M. Sweet
  • Ron C. Michaelis


This chapter describes the progress that has been made in personalizing medicine in several fields other than cancer and cardiovascular disease. A brief review is given of the gene variants that help predict, diagnose and treat age-related macular degeneration, type 2 diabetes mellitus, psychiatric disorders, substance abuse, Alzheimer disease and age-related cognitive decline, asthma and other respiratory disorders. The chapter discusses the clinically useful tests that have already been developed, several promising early discoveries that must now be reevaluated, and a number of basic research discoveries that will provide the basis for developing clinically useful tests in the near future.


Alzheimer Disease COMT Gene Prefrontal Lobe Nongenetic Factor COMT Polymorphism 
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Further Readings

  1. Bobb AJ, Castellanos FX, Addington AM, Rapoport JL (2005) Molecular genetic studies of ADHD: 1991 to 2004. Am J Med Genet B Neuropsychiatr Genet Jan 5;132B(1):109–25PubMedGoogle Scholar
  2. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry Jun 1;57(11):1313–23PubMedCrossRefGoogle Scholar
  3. Lunshof JE, Bobe J, Aach J, Angrist M, Thakuria JV, Vorhaus DB, Hoehe MR, Church GM (2010) Personal genomes in progress: from the human genome project to the personal genome project. Dialogues Clin Neurosci 12(1):47–  60PubMedGoogle Scholar
  4. Munafò MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, Järvelin MR, Taanila A, Flint J (2009) 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet Mar 5;150B(2):271– 81PubMedCrossRefGoogle Scholar
  5. Rubinsztein DC, Easton DF (1999) Apolipoprotein E genetic variation and Alzheimer’s disease. A meta-analysis. Dement Geriatr Cogn Disord May-Jun;10(3):199 –209PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Clinical Cancer Genetics and Medical GeneticsThe Ohio State UniversityColumbusUSA
  2. 2.Biology DepartmentWestern Carolina UniversityCullowheeUSA

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