• María Luisa EscobarEmail author
  • Gerardo H. Vázquez-Nin
  • Olga M. Echeverría


Morphological features of oncosis are characterized by cell and ­organelle swelling and disruption; nucleus is initially preserved and later undergoes karyolysis and caspase-independent DNA fragmentation. The mitochondrial generation of ATP requires the presence of an electrochemical gradient; a reduction in mitochondrial membrane potential frequently precedes the morphological changes seen in oncotic cells. Oncotic cell death is characterized by early plasma membrane rupture and disruption of organelles including mitochondria. The plasma membrane breakdown allows the outflow of cell components, which affects near or distant organs.


Mitochondrial Membrane Potential Pancreatic Acinar Cell Nicotinamide Adenine Dinucleotide Oesophageal Squamous Cell Carcinoma Proximal Tubule Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations


Adenosine triphosphate


Deoxyribonucleic acid


Reactive oxygen species


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • María Luisa Escobar
    • 1
    Email author
  • Gerardo H. Vázquez-Nin
    • 1
  • Olga M. Echeverría
    • 1
  1. 1.Laboratory of Electron Microscopy, Department of Cell Biology, Faculty of SciencesNational University of Mexico (UNAM)MexicoUSA

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