• María Luisa Escobar
  • Gerardo H. Vázquez-Nin
  • Olga M. Echeverría


Cell death is a fundamental physiological process involved in controlling the balance between proliferation and differentiation during embryonic development, and in the renewal of cellular tissue throughout adulthood. It is presently known that some alterations in this process modify the cellular behavior and can lead to different pathologies, such as certain cancers and neurodegeneration processes. Apoptosis is the best studied cell death, and it is considered as programmed type I cell death. This process is characterized by several morphological cellular changes where ­cellular shrinkage, chromatin condensation, nuclear fragmentation are included. The apoptosis is executed by a group of proteases, denominated caspases, which lead to the cellular characteristics of the process.


Flavin Adenine Dinucleotide Nuclear Localization Sequence WD40 Repeat Executer Caspases Mitochondrial Intermembrane Space 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations


Apoptotic protease activating factor 1


Bcl-2 antagonist/killer


Bcl-2-associated X protein


Bcl-2-homology domain-3




Caspases recruitment domain


Caenorhabditis elegans cell-death abnormality-3


Death effector domain


Death-inducing signaling complex


Fas associated death domain-containing protein


Interleukin-1 converting enzyme


Myeloid cell leukemia-1


Mitochondrial outer-membrane permeabilization


p53-Indicible death domain


p53-Upregulated modulator of apoptosis


Second mitochondrial activator of caspase/direct IAP-binding protein with low pI


Truncated BID


TNF receptor


Tumor necrosis factor


TNFR1-associated death domain


TNF-related apoptosis-inducing ligand


X-linked inhibitor of apoptosis protein


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • María Luisa Escobar
    • 1
  • Gerardo H. Vázquez-Nin
    • 1
  • Olga M. Echeverría
    • 1
  1. 1.Laboratory of Electron Microscopy, Department of Cell Biology, Faculty of SciencesNational University of Mexico (UNAM)MexicoUSA

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