Follicular Cells

  • María Luisa EscobarEmail author
  • Gerardo H. Vázquez-Nin
  • Olga M. Echeverría


Atresia occurs in neonate, as well as in prepubertal organisms, the ­follicles that reach the antral follicular phase will inevitably be eliminated as a ­consequence of diverse causes as the absence of the hormone source present once the organism reach puberty. Most follicles appear to undergo atresia at an earlier stage of growth. Basal concentration of gonadotropins appears sufficient to maintain follicle growth to small antral stage only. Prepubertal mice ovaries possess a mixture of late preantral and early antral follicles destined to atresia due to inadequate gonadotropin support prior to puberty. Therefore, before the onset of puberty, the normal fate of growing follicles is atretic demise. Observations of the ovary atresia demonstrated that in neonate and prior to puberty most atresia occurs in preantral follicles.


Granulosa Cell Antral Follicle Primordial Follicle Follicular Development Preantral Follicle 
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List of Abbreviations


Luteinizing hormone


Follicle stimulant hormone


Transforming growth factor beta


Epidermal growth factor


Terminal Deoxy-UTP nick end labeling. Procedure that detects DNA breaks


Apoptotic protease activating factor 1


Activin receptor-like kinase 7


Basic fibroblast growth factor


B-cell lymphoma 2


Bcl-2-related ovarian killer


Cyclic adenosine monophosphate






Equine chorionic gonadotropin


Fas ligand


Flice-like inhibitory protein isoform


Follicle stimulant hormone-receptor


Human inhibitor of apoptosis protein-2


Inhibitor of apoptosis proteins


Insulin-like growth factor-I




Nitric oxide


Nuclear factor κB


Pregnant mare serum gonadotropin


Reactive oxygen species


Tumor necrosis factor-alpha


X-link inhibitor of apoptosis protein


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • María Luisa Escobar
    • 1
    Email author
  • Gerardo H. Vázquez-Nin
    • 1
  • Olga M. Echeverría
    • 1
  1. 1.Laboratory of Electron Microscopy, Department of Cell Biology, Faculty of SciencesNational University of Mexico (UNAM)MexicoUSA

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