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Prefollicular Cells

  • María Luisa Escobar
  • Gerardo H. Vázquez-Nin
  • Olga M. Echeverría
Chapter

Abstract

Initially the ovarian cords are formed by pre-granulosa somatic cells and oogonia, which are become oocytes at the meiotic S phase. Pre-granulosa-oocyte interactions, through cell contacts and/or by means of paracrine factors, promote oocyte survival. During prefollicular phase the somatic cell death is infrequent, this has been shown in diverse studies involving different animal models. For instance, in sheep pre-granulosa cells present in ovigerous cords do not appear to be affected by apoptosis. However, recent studies demonstrated the expression of Bok, Bcl-X(L), TNF and full length and cleaved caspase-3 in fetal ovaries, with specific patterns in oocytes and in pre-granulosa cells. However, recent studies demonstrated the expression of Bok, Bcl-X(L), TNF and full length and cleaved caspase-3 in fetal ovaries, with specific patterns in oocytes and in pre-granulosa cells. Bok markedly reduces vulnerability to apoptosis, conversely, loss of Bcl-X(L) increases apoptosis. These results suggest important roles for Bok and Bcl-X(L) in human ovarian development.

Keywords

Germ Cell Granulosa Cell Primordial Follicle Premature Ovarian Failure Meiotic Prophase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

Smad4

Tumor suppressor gene

Notch

A receptor protein and the signaling pathway mediated by this protein.

Wnt

Protein that are secreted as signal molecules

β-catenin

Protein that functions as cell-cell adhesion and as a gen regulatory protein

RSPO1

R Spondin 1

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • María Luisa Escobar
    • 1
  • Gerardo H. Vázquez-Nin
    • 1
  • Olga M. Echeverría
    • 1
  1. 1.Laboratory of Electron Microscopy, Department of Cell Biology, Faculty of SciencesNational University of Mexico (UNAM)MexicoUSA

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