Biologically Active Substances of Selected Flagellates
Exogenous lipids isolated from various natural sources can reduce the destructive effect of tumors and elicit a cytotoxic effect in the malignant cells. Results were reviewed (Sukhareva, 1975; 1989; Holman, 1981; Gurr, 1983; Bogoslovskaya 1984; Begin et al., 1985) and new data have recently been obtained (Kimura, 2002; Yu et al., 2002). In many studies, the antitumor activity of lipids from shark liver, the thymus of various animals, from protozoa and bacteria has been demonstrated (Kasai et al., 1961; Yamamoto et al., 1962; Katchman et al., 1963; Kato et al., 1969; Kato et al., 1971; Kigoshi, 1971; O’Daly et al., 1979; Asahi at al., 1986; Sukhareva et al., 1991; Kaya et al., 1995). The usual range of experimental murine tumors used by various authors includes sarcoma 180, carcinoma 755, Ehrlich ascitic carcinoma or carcinoma 755, Lewis lung carcinoma, and leukemia P-338.
KeywordsPeritoneal Macrophage Antiradical Activity Ehrlich Ascitic Carcinoma Sucrose Ester Mouse Spleen Cell
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