The paradox: vasoconstriction and vasodilation

  • Yasuko Iwakiri
  • Roberto J. Groszmann


One of the most typical characteristics observed in patients with chronic liver diseases is the progressive alteration of the body’s homeostatic mechanisms. Electrolyte imbalances, impaired oxygenation and ventilation, as well as abnormalities in vascular tone, are among some of the altered homeostatic functions observed in these patients1. Nitric oxide (NO), a key molecule that regulates vascular tone, plays a major role in the pathogenesis of the hyperdynamic circulatory syndrome observed in portal hypertension in liver diseases. NO is paradoxically regulated in portal hypertension (Figure 1).


Nitric Oxide Portal Hypertension Superior Mesenteric Artery Portal Pressure eNOS Activity 
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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Yasuko Iwakiri
  • Roberto J. Groszmann
    • 1
  1. 1.VA Connecticut Healthcare SystemHepatic Hemodynamic Laboratory/111JWest HavenUSA

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