The role of hepatic stellate cells/myofibroblasts

  • Massimo Pinzani
Conference paper


The recognition that HSC are provided with contractile properties represents a key acquisition in the knowledge of the biology of this cell typex1. Contraction of activated HSC occurs in vitro in response to different vasoconstrictors. This experimental evidence is representative of HSC contractile status in fibrotic liver, where contraction of activated HSC in response to various stimuli may have important implications in the pathogenesis of portal hypertension and in the contraction of mature scar tissue. Following the demonstration that culture-activated human and rat HSC are able to contract in response to different vasoconstrictors2, 3, the potential involvement of this cell type in the genesis and progression of portal hypertension has been postulated. The presence of a contractile cell type operating in liver sinusoids and in developing scar tissue reinforced the concept of a dynamic component for the increased intrahepatic resistance in cirrhotic liver modifiable by vasodilators4.


Portal Hypertension Hepatic Stellate Cell Cirrhotic Liver Cell Contraction Fibrotic Liver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Massimo Pinzani
    • 1
  1. 1.Dipartimento di Medicina InternaUniversita degli Studi di FirenzeFirenzeItaly

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