Inhibition of nitric-oxide-mediated vasodilation (including K+ channels)

  • Richard Moreau
Conference paper


Portal hypertension is associated with a chronic hyperkinetic syndrome1, 2, 3. This syndrome is characterized by elevated cardiac output, low arterial pressure and low systemic vascular resistance2, 3. Splanchnic circulation is also hyperdynamic; i.e. blood flow is elevated and vascular resistance is low in arteries that supply splanchnic organs1, 4. Systemic and splanchnic alterations are interrelated: decreased systemic vascular resistance (systemic vasodilation) is largely due to the decrease in splanchnic arterial resistance (splanchnic vasodilation)5. Finally, in portal hypertension, there is in-vivo and ex-vivo arterial hypo reactivity to different receptor-dependent and -independent vasoconstrictors6, 7, 8, 9, 10, 11, 12, 13, 14. A hyperkinetic syndrome also occurs in extrahepatic portal hypertension15, but it is less marked than that observed in cirrhosis.


Nitric Oxide Portal Hypertension Bacterial Translocation eNOS Phosphorylation Hyperdynamic State 
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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Richard Moreau
    • 1
  1. 1.Service hepato-gastroenterologieINSERM U-481, Hopital BeaujonClichyFrance

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