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NCX-1000: a liver-specific NO donor

  • Stefano Fiorucci
  • Elisabetta Antonelli
  • Antonio Morelli
Conference paper

Abstract

Recent advances in the knowledge of the pathophysiology of portal hypertension show that cirrhotic liver exhibits endothelial dysfunction of sinusoidal endothelial cells. This alteration results in a defective or absent vasodilatory response to acetylcholine and in insufficient nitric oxide (NO) production by endothelial NO synthase in the intrahepatic vascular bed. Such deficient NO production increases hepatic vascular tone, and may decrease the intrahepatic vasodilatory adaptive response to sudden increases in blood flow1, 2, 3. Therefore, drugs that deliver NO to the intrahepatic circulation, such as nitrates, should be able to compensate for reduced NO generation and reduce portal pressure gradient. For this reason vasodilators have been studied in recent years as a possible alternative to β-blockers in the pharmacologic treatment of portal hypertension.

Keywords

Nitric Oxide Portal Hypertension Ursodeoxycholic Acid Portal Pressure Isosorbide Dinitrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Stefano Fiorucci
    • 1
  • Elisabetta Antonelli
  • Antonio Morelli
  1. 1.Department of GastroenterologyUniversity of PerugiaPerugiaItaly

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