Clinical toxicology is a rapidly growing and changing field in medicine today. Common substances, over the counter medications, prescription drugs and illicit drugs can all be responsible for poisonings and overdoses leading to clinical symptoms. Poisonings most commonly occur in children and the elderly, while intentional overdoses are becoming an increasing problem in adolescents. Thus, pediatric nephrologists are often confronted by a patient requiring medical intervention for poisonings and overdoses. When the American Academy of Pediatrics established an Accident Prevention committee in 1952 they found that 50% of all accidents involved poisoning and that 25% of these poisonings were caused by flavored children’s aspirin. Although the advent of safety closures for drug containers has reduced this number, poisonings remain a significant problem. The work of George Schreiner at Georgetown University led to the use of dialysis and other extracorporeal modalities as therapeutic regimens available to the practitioner for the treatment of poisoning and overdose.
KeywordsPeritoneal Dialysis Continuous Renal Replacement Therapy Blood Flow Rate Active Removal Poison Control Center
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