Functional, Self-Referential Genetic Coding

  • Romeu Cardoso Guimarães
  • Carlos Henrique
  • Costa Moreira
Part of the Cellular Origin and Life in Extreme Habitats and Astrobiology book series (COLE, volume 7)

Abstract

A model for the genetic code structure and organization is presented. It is self-referential due to starting without an mRNA to be translated. Recruitment of tRNAs occurs in pairs, one fishing the other, their anticodons being simultaneously codons for each other. Genes — mRNAs — arise in the process of formation of the code. It is also functional, depicting various consistent correlations with protein properties. First attributions — Gly, Pro, Ser — are the outliers from the hydropathy correlation, protein-stabilizing and RNA-binding amino acids. These properties allow formation of a stable RNP system, the source-product relationship being established. The succession of entries also obeys the following criteria: (a) synthetases class II to class I; (b) protein conformations from aperiodic to helices and then strands; (c) ordering of protein sequences with heads and tails, respectively, stable and unstable, called a non-specific punctuation system, in the second stage; (d) DNA-binding amino acids in the third stage; (e) late development of the specific punctuation system, that of initiation defining the stop signs, and (f ) of the hexacodonic expansions of Leu and Arg.

Keywords

Genetic Code Stop Sign Protein Property Federal Mina Letter Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Refrences

  1. Guimarães, R.C. (1996) Anticomplementary order in the genetic coding system, Abstracts of the International Conference on the Origin of Life, ISSOL, Orléans, 11: 100.Google Scholar
  2. Guimarães, R.C. (2001) Two punctuation systems in the genetic code, In: J. Chela-Flores, T. Owen and F. Raulin (eds.) First Steps in the Origin of Life in the Universe, Kluwer, Dordrecht, pp. 91–94.Google Scholar
  3. Guimarães, R.C. and Moreira, C.H.C. (2002) Genetic code structure and evolution: aminoacyl-tRNA synthetases and principal dinucleotides, In: G. Pályi, C. Zucchi and L. Caglioti (eds.) Fundamentals of Life, Elsevier, Paris, pp. 249–276.Google Scholar
  4. 1.
    Guimarães, R.C. and Moreira, C.H.C. (2004) The functional and self-referential genetic code, In: G. Pályi, C. Zucchi and L. Caglioti (eds.) Progress in Biological Chirality, Elsevier, Oxford, pp. 83–118.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Romeu Cardoso Guimarães
    • 1
  • Carlos Henrique
    • 1
  • Costa Moreira
    • 2
  1. 1.Dept. Biologia Geral, Inst. Ciências BiológicasUniv. Federal Minas GeraisBrasil
  2. 2.Dept. Matemática, Inst. Ciências ExatasUniv. Federal Minas GeraisBrasil

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