Lipoic Acid, a Metabolic Antioxidant Stimulates the Insulin Signaling Pathway in Adipocytes and Counteracts Oxidative Stress and Age Related Mitochondrial and Cognitive Dysfunction

  • Lester Packer
Conference paper
Part of the NATO Science Series book series (NAII, volume 129)

Abstract

Healthy aging and disease prevention by antioxidant nutrition is increasingly a subject of academic and public health interest and research. Antioxidants play an important role in maintaining physiological redox status of cellular constituents against free radicals. Antioxidants may change their redox state, be targeted for destruction, regulate oxidative processes involved in signal transduction, affect gene expression and pathways of cell proliferation, as well as differentiation and death. This chapter will provide an overview of the antioxidant defense system with special relevance to the brain and aging.

Keywords

Insulin Receptor Lipoic Acid Insulin Signaling Pathway Redox Regulation Thioctic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • Lester Packer
    • 1
  1. 1.Department of Molecular Pharmacology and Toxicology School of Pharmacy, Health Sciences CampusUniversity of Southern CaliforniaLos AngelesUSA

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