Chemical Probes in Biology pp 137-144 | Cite as
Lipoic Acid, a Metabolic Antioxidant Stimulates the Insulin Signaling Pathway in Adipocytes and Counteracts Oxidative Stress and Age Related Mitochondrial and Cognitive Dysfunction
Conference paper
Abstract
Healthy aging and disease prevention by antioxidant nutrition is increasingly a subject of academic and public health interest and research. Antioxidants play an important role in maintaining physiological redox status of cellular constituents against free radicals. Antioxidants may change their redox state, be targeted for destruction, regulate oxidative processes involved in signal transduction, affect gene expression and pathways of cell proliferation, as well as differentiation and death. This chapter will provide an overview of the antioxidant defense system with special relevance to the brain and aging.
Keywords
Insulin Receptor Lipoic Acid Insulin Signaling Pathway Redox Regulation Thioctic Acid
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References
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© Springer Science+Business Media Dordrecht 2003