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Bacterial Adhesion pp 17–34Cite as

Adhesive Mechanisms of Salmonella enterica

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 715)

Abstract

Salmonella enterica is an invasive, facultative intracellular pathogen of animal and man with the ability to colonize various niches in diverse host organisms. The pathogenesis of infections by S. enterica requires adhesion to various host cell surfaces, and a large number of adhesive structures can be found. Depending on the serotype of S. enterica, gene clusters for more than 10 different fimbrial adhesins were identified, with type I fimbriae such as Fim, Lpf (long polar fimbriae), Tafi (thin aggregative fimbriae) or the type IV pili of serotype Typhi. In addition, autotransporter adhesins such as ShdA, MisL and SadA and the type I secreted large repetitive adhesins SiiE and BapA have been identified. Although the functions of many of the various adhesins are not well understood, recent studies show the specific structural and functional properties of Salmonella adhesins and how they act in concert with other virulence determinants. In this chapter, we describe the molecular characteristics of Salmonella adhesins and link these features to their multiple functions in infection biology.

Keywords

  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Adhesion System
  • Adhesive Structure
  • Cystic Fibrosis Transmembrane Conductance Regulator Mutation
  • Salmonella Pathogenicity Island

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Acknowledgements

Work in our laboratory was supported by grants of the Deutsche Forschungsgemeinschaft (DFG) and the Staedtler-Stiftung.

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  1. Mikrobiologisches Institut, Universitätsklinikum Erlangen, Erlangen, 91054, Germany

    Carolin Wagner

  2. Fachbereich Biologie/Chemie, Abteilung Mikrobiologie, Universität Osnabrück, 49076, Osnabrück, Germany

    Michael Hensel

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  1. , Department I, Protein Evolution, Max-Planck Institute for Developmental B, Spemannstr. 35, Tübingen, 72076, Germany

    Dirk Linke

  2. , Institute of Biotechnology, University of Helsinki, Viikinkaari 1, Helsinki, FIN-00014, Finland

    Adrian Goldman

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Wagner, C., Hensel, M. (2011). Adhesive Mechanisms of Salmonella enterica . In: Linke, D., Goldman, A. (eds) Bacterial Adhesion. Advances in Experimental Medicine and Biology, vol 715. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0940-9_2

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