Abstract
As with the other acrocentric chromosomes, the centromere, short arm and satellite regions of chromosome 15 are variable in size and staining properties (Figs. 20.1–20.3). Current FISH analyses distinguish at least two classes of repetitive DNA in the heterochromatin of chromosome 15: (1) a chromosome 15-specific alpha satellite DNA in the pericentromeric region of chromosome 15 (Choo et al., Genomics 7:143–151, 1990) and (2) a chromosome 15-specific subcomponent of satellite III DNA that comprises a major component of the short arm of chromosome 15 (Higgins et al., Chromosoma 93:77–86, 1985; Fowler et al., Hum Genet 79:265–272, 1988). Cross hybridization of a chromosome 15-specific satellite III with other D-group chromosomes was reported in 5.5% of subjects in one study, and was correlated with additional DA/DAPI-positive signals on those chromosomes (Smeets et al., Hum Genet 87:45–48, 1991). Cross hybridization of D15Z1 with chromosome 14 occurs in about 12% of cases (Fig. 30.1) (Stergianou et al., Hereditas 119:105–110, 1993; Shim et al., Am J Gen Tech 29:146–151, 2003; Cockwell et al., Europ J Hum Genet 15:441–445, 2007).
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Wyandt, H.E., Tonk, V.S. (2011). Chromosome 15. In: Human Chromosome Variation: Heteromorphism and Polymorphism. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0896-9_20
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DOI: https://doi.org/10.1007/978-94-007-0896-9_20
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