Chromosome 9

  • Herman E. Wyandt
  • Vijay S. Tonk


The lightly-stained secondary constriction of chromosome 9 by plain Giemsa distinguishes it from other C-group chromosomes (Patau et al., Lancet i:790–793, 1960; Ferguson-Smith et al., Cytogenetics 1:325–343, 1962; Palmer and Funderburk, Cytogenetics 4:261–276, 1965). By G-banding, the secondary constriction itself stains lightly, but bands on either side of the centromere typically stain as intensely as the pericentromeric regions of other chromosomes (Fig. 14.1a–i). By C-banding or DA/DAPI staining, the entire region, including the pericentromeric bands usually consists of a uniform block of dark or brightly staining heterochromatin (Fig. 14.1m, n). Sometimes, however, blocks of heterochromatin will appear to be separated by a G-positive, C-negative band (Fig. 14.1j, k). More rarely, such C-negative bands can be quite striking and have been the object of considerable study (see Euchromatic Variants). The 9qh region is also strikingly stained by Giemsa-11 (Fig. 2.4) (Bobrow et al., Nature New Biol 238:122–124, 1972; Wyandt et al., Exp Cell Res 102:85–94, 1976).


Down Syndrome Pericentric Inversion Secondary Constriction Complete Inversion Idiopathic Mental Retardation 
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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Boston University School of Medicine Center for Human GeneticsBostonUSA
  2. 2.Acupath Laboratories, Inc.PlainviewUSA
  3. 3.Department of PediatricsTexas Tech University Health Science CenterLubbockUSA

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