Chromosome 5

Chapter

Abstract

A rare variant of chromosome 5, detected prenatally, consisted of a large pericentromeric block of heterochromatin that was C and G-11 positive. It was also present in several family members, all of whom were phenotypically normal (Fig. 10.1) (Fineman et al., Am J Med Genet 32:498–499, 1989). In a more recent report of a three-generation family (Doneda et al., Chromosome Res 6:411–414, 1998), FISH studies showed a similar variant that hybridized with satellite III sequences but not with beta satellite sequences of chromosome 9. Earlier studies (Buhler et al., Humangenetik 26:329–333, 1975) had shown G-11 staining to correlate to the locations of satellite III on several chromosomes, especially on chromosome 9.

Keywords

Rare Variant Interstitial Deletion Band 5p13 Alpha Satellite Satellite Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Boston University School of Medicine Center for Human GeneticsBostonUSA
  2. 2.Acupath Laboratories, Inc.PlainviewUSA
  3. 3.Department of PediatricsTexas Tech University Health Science CenterLubbockUSA

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