Very High Protein Production Levels with a New Transient and Serum-Free Expression System Based on Human CAP Cells

  • Corinna Bialek
  • Sabine Hertel
  • Nadine Scholz-Neumann
  • Ruth Essers
  • Gudrun Schiedner
Conference paper
Part of the ESACT Proceedings book series (ESACT, volume 5)

Abstract

Human CAP (CEVEC’s Amniocyte Production) cells allow for stable production of recombinant proteins with excellent biologic activity and therapeutic efficacy as a result of authentic posttranslational modification. Based on human CAP cells a new transient expression system has been developed, that is scalable and serum-free and enables extremely high production yields of recombinant proteins within a few days. The novel CAP-T transient human cell expression system is a rapid and versatile tool for fast and serum-free protein expression for screening, assay development, drug discovery and early stage pre-clinical drug development. From gene to mg amounts within two weeks – fast process times and high yields even for highly glycosylated proteins are key feature of the CAP-T expression system.

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Corinna Bialek
    • 2
  • Sabine Hertel
    • 2
  • Nadine Scholz-Neumann
    • 2
  • Ruth Essers
    • 3
  • Gudrun Schiedner
    • 1
  1. 1.CEVEC Pharmaceuticals GmbHKölnGermany
  2. 2.CEVEC Pharmaceuticals GmbHCologneGermany
  3. 3.CEVEC Pharmaceuticals GmbHKölnGermany

Personalised recommendations