Abstract
In normal human beings baseline myocardial energy expenditure in the anterior wall of the left ventricle, calculated from arterial and great cardiac vein substrate concentration and blood flow, amounts to 34±5 cal/min, which means roughly 2–3 times as much for the whole left ventricle. In the post- absorptive state energy is derived almost entirely from free fatty acids and 301±53 pmol/min of oxygen are required for their oxidation. If heart rate is doubled by atrial pacing from 80 to 160 beats per minute, energy expenditure increases to 64±7 cal/min and oxygen consumption to 593±71 pmol/min. These changes occur despite a fall in transmyocardial oxygen extraction from 71+3 to 64+3% from baseline to pacing tachycardia. The additional oxygen required can therefore be delivered only through an increase in myocardial blood flow which, in this particular case, is more than doubled1.
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Camici, P.G., Rimoldi, O. (1998). The Coronary Microcirculation and Myocardial Ischemia. In: Van Der Wall, E.E., Blanksma, P.K., Niemeyer, M.G., Vaalburg, W., Crijns, H.J.G.M. (eds) Advanced Imaging In Coronary Artery Disease. Developments in Cardiovascular Medicine, vol 202. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0866-2_6
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DOI: https://doi.org/10.1007/978-94-007-0866-2_6
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