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Schizo-Obsessive Disorder

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Handbook of Schizophrenia Spectrum Disorders, Volume II

Abstract

Obsessive-compulsive features are common in schizophrenia. The term schizo-obsessive has been proposed to delineate this subgroup of schizophrenia patients who also present OCS/OCD. Research into clinical, neuropsychological and functional profiles of schizo-obsessive patients has been extensive during these last years although a specific profile has yet to emerge. In addition, the neurobiological and genetic underpinnings of this association have recently begun to be investigated with preliminary but promising results. This chapter reviews the validity of schizo-obsessive disorder. The clinical and neuropsychological profile is elucidated and possible pathophysiological mechanisms and etiologic factors are discussed. Finally, a suitable therapeutic approach is also suggested.

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Abbreviations

AP:

Antipsychotic

CANTAB:

Cambridge automated neuropsychological test battery

COMT:

Catechol-O-methyltransferase

DLPC:

Dorsolateral prefrontal cortex

DSM:

Diagnostic and statistical manual for mental disorders

ERP:

Event-related potentials

fMRI:

Functional magnetic resonance imaging

MRI:

Magnetic resonance imaging

OFC:

Orbito-frontal Cortex

OC:

Obsessive-compulsive

OCD:

Obsessive compulsive disorder

OCPD:

Obsessive-compulsive personality disorder

OCS:

Obsessive-compulsive symptoms

SSRI:

Selective serotonin reuptake inhibitor

UHR:

Ultra high risk

WCST:

Wisconsin card sorting test

YBOCS:

Yale Brown obsessive-compulsive scale

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Acknowledgments

The authors acknowledge the generous assistance of Tom Hardy.

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Authors and Affiliations

  1. Unitat d’Hospitalizació Psiquiàtrica Penitenciària de Catalunya (UHPP-C), Parc Sanitari de Sant Joan de Déu, Sant Esteve Sesrovires, Barcelona, Spain

    Ruth Cunill

  2. Servei de Psiquiatria, Hospital Universitari Vall d’Hebron, Barcelona, Spain

    Xavier Castells

  3. Departament de Farmacologia, de Terapèutica i de Toxicologia, Universitat Autònoma de Barcelona, Barcelona, Spain

    Xavier Castells

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  1. Ruth Cunill
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  2. Xavier Castells
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Correspondence to Ruth Cunill .

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Editors and Affiliations

  1. , Rappaport Faculty of Medicine, Technion - Israel Institute of Technolog, Haifa, Israel

    Michael Ritsner

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Cunill, R., Castells, X. (2011). Schizo-Obsessive Disorder. In: Ritsner, M. (eds) Handbook of Schizophrenia Spectrum Disorders, Volume II. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0831-0_17

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