The chemistry of acyclic nucleosides

  • L. A. Agrofoglio
  • S. R. Challand

Abstract

This chapter will cover chemical methods for gaining access to acyclic nucleosides. Brief reference will be made in passing to activities of compounds as they are described but major aspects of their biological activity are dealt with in detail in the next chapter. In order to maintain consistency in terms of mechanism of action we will, with one exception (see section 1.6.1), restrict our survey to acyclic nucleosides that possess an hydroxymethyl group equivalent to the 5′-hydroxyl of a conventional nucleoside, i.e. a hydroxyl which can be metabolized into the active triphosphate analogue. Such compounds are in principle capable of acting as anti-virals or anti-tumour agents by interfering, at the triphosphate level, with nucleic acid polymerases.

Keywords

Thymidine Kinase Methyl Chloride Acyclic Nucleoside Acyclic Analogue Nucleoside Nucleotide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • L. A. Agrofoglio
    • 1
  • S. R. Challand
    • 2
  1. 1.Université d’OrléansOrléansFrance
  2. 2.BeckenhamUK

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