General introduction

  • L. A. Agrofoglio
  • S. R. Challand

Abstract

Interest in chemical entities capable of blocking or modifying cell metabolism ultimately goes back to the discovery of the structure of DNA in the 1950s. The understanding of the biochemical processes by which DNA controls cell viability in vivo rapidly led to the idea that compounds could be designed and synthesized which might interfere with one or more of these processes. Several classes of drug have since been discovered which depend for their effect on some kind of modification of the proper functioning of nucleic acids. Intercalators and alkylating agents were among the earliest therapeutic agents which were recognized as behaving in this way and were widely used as treatments for bacterial infections and some forms of cancer. It was a small but significant step forward to arrive at the notion that analogues of the four natural nucleoside components of DNA might have similar effects. The result was multifarious programmes of research aimed at synthesizing such compounds and investigating their effects on biological and biochemical systems.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Thymidine Kinase Nucleoside Analogue General Introduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • L. A. Agrofoglio
    • 1
  • S. R. Challand
    • 2
  1. 1.Université d’OrléansOrléansFrance
  2. 2.BeckenhamUK

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