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Nature and Nurture: Impacts on Mouse Phenotypes and Translational Research

  • Cory Brayton
Chapter

Abstract

While genome projects continue to provide crucial information about the structure of genomes and their genes, functional genomics (or functional genetics) initiatives strive to understand the function of genomes and their genes. Identification of a protein gene product and determination of its function as a receptor, ligand or enzyme is a proximal goal. Understanding the role of the gene and its product, in the context of a living organism, in its environment is the ultimate goal of functional genomics initiatives. Thus, functional genomics efforts in genetically engineered animals aim to produce and characterize phenotype(s) that clearly result from the intended genetic manipulation(s) and help to elucidate gene function(s). However, phenotypes reflect genetic influences other than the intended genetic manipulations, as well as experiential and environmental influences including infectious agents. Potential impacts of extra-experimental variables must be considered when interpreting phenotype data.

Keywords

Histopathology Finding Mouse Mammary Tumor Virus Alopecia Areata Corneal Opacity Genetically Modify Organism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins UniversityBaltimoreUSA

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