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The Role of Cancer-Associated Adipocytes (CAA) in the Dynamic Interaction Between the Tumor and the Host

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Tumor-Associated Fibroblasts and their Matrix

Part of the book series: The Tumor Microenvironment ((TTME,volume 4))

Abstract

Adipose tissue can act as an effector organ that influences both cancer risk and tumor behavior. This review will focus on the emerging role of adipocytes in cancer progression. To date, the exact mechanisms by which adipocytes promote an aggressive cancer phenotype are poorly understood. Critical aspects of cancer cell-adipocyte interaction/cross-talk will be discussed. Tumor progression may depend on the specific “activation” by invading cancer cell stimuli of cancer-associated adipocytes (CAAs). In addition to local function, CAAs have also systemic effects that impact on tumorigenesis. Interestingly, there are similarities between CAA- and obesity -related alterations of cytokines, adipokines and hormones, providing some molecular insights into the reported pejorative link between obesity and cancer.

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Acknowledgements

We thank Susan Chan for helpful discussion. This work was supported by funds from the Institut National de la Santé et de la Recherche Médicale, the Centre National de la Recherche Scientifique, the Hôpital Universitaire de Strasbourg, the Association pour la Recherche sur le Cancer, the Ligue Nationale Française Contre le Cancer and the Comités du Haut-Rhin et du Bas-Rhin, the Fondation de France, the European Commission (FP6 LSHC-CT-2003–503297; Cancer Degradome project), the Institut National du Cancer, Fond National pour la Santé ACI 2004 Cancéropôle Grand-Est, and the “Ruban Rose” prize.

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Rio, MC. (2011). The Role of Cancer-Associated Adipocytes (CAA) in the Dynamic Interaction Between the Tumor and the Host. In: Mueller, M., Fusenig, N. (eds) Tumor-Associated Fibroblasts and their Matrix. The Tumor Microenvironment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0659-0_6

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