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Tumor-Associated Fibroblasts and their Matrix pp 23–36Cite as

Functional Diversity of Fibroblasts

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Part of the book series: The Tumor Microenvironment ((TTME,volume 4))

Abstract

Solid tumours are multi-cellular tissues comprised of tumour cells and stromal cells, including fibroblasts, endothelial cells and inflammatory cells. When a cancer cell metastasizes, it first will be exposed to cancer associated fibroblasts in the immediate tumour microenvironment and subsequently to normal fibroblasts as it traverses the underlying connective tissue on its way to the bloodstream. So far, the interactions of tumour cells with stromal fibroblasts influence tumour biology by mechanisms that are not yet fully understood. It is known that cells of the tumour parenchyma and stroma are in extensive crosstalk, and the composition of the stroma and the nature of tumour stromal interactions change over time with tumour progression (Beacham and Cukierman, Semin Cancer Biol 15:329–341, 2005; Proia and Kuperwasser, Cell Cycle 4:1022–1025, 2005). The tumour-stroma crosstalk markedly influences not only tumour growth by modifying and controlling angiogenesis, suppressing or subverting immune responses of the host, but also by modulating extracellular matrix composition, and secreting factors which in turn stimulate cells to further alter cell physiology as well as the cellular and acellular composition of the tumour microenvironment (Stuelten et al., PlosOne 5:e9832, 2010; Olumi et al., Cancer Res 59:5002–5011, 1999; Liotta and Kohn Nature 411:375–379, 2001).

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Authors and Affiliations

  1. Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tübingen, Röntgenweg 11, 72076, Tübingen, Germany

    H. Peter Rodemann

  2. Hospital for Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Hannover, Germany

    Hans-Oliver Rennekampff

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  1. H. Peter Rodemann
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Correspondence to H. Peter Rodemann .

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Editors and Affiliations

  1. Siederstrasse 13, Villingen-Schwenningen, 78054, Germany

    Margareta M. Mueller

  2. Am Pferchelhang 32, Heidelberg, 69118, Germany

    Norbert E. Fusenig

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Rodemann, H.P., Rennekampff, HO. (2011). Functional Diversity of Fibroblasts. In: Mueller, M., Fusenig, N. (eds) Tumor-Associated Fibroblasts and their Matrix. The Tumor Microenvironment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0659-0_2

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