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Tumor-Associated Fibroblasts and their Matrix pp 175–193Cite as

Tumor Fibroblast-Associated Metalloproteases

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Part of the book series: The Tumor Microenvironment ((TTME,volume 4))

Abstract

Matrix metalloproteinases (MMPs) and the closely related ADAM (a disintegrin and metalloproteinase domain) and ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) are soluble or membrane-anchored proteolytic enzymes that can degrade components of the extracellular matrix (ECM) as well as a growing numbers of modulators of cell functions. Our knowledge about the multifaceted contribution of these enzymes in all steps of cancer progression is rapidly expanding. The functional exploration of these cancer-associated enzymes led to a change in the way we view cancer and particularly the tumor-host interface. Several of these enzymes are produced by fibroblastic cells infiltrating the tumor rather than by tumor cells themselves, and therefore might be considered as key molecular determinants of the tumor microenvironment. In this review, we explore the different faces of fibroblastic-associated MMPs and ADAMTSs.

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Acknowledgments

This work was supported by grants from Ministerio European projects (FP7 HEALTH-F2-2008-201279 “MICROENVIMET”), the Fondation contre le Cancer, the D.G.T.R.E. from the « Région Wallonne », the Interuniversity Attraction Poles Programme—Belgian Science Policy (Belgium). DE is grateful to support from the Breast Cancer Campaign, Cancer Research-UK and the Big C Appeal.

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  1. Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer (GIGA-Cancer), University of Liège, Sart Tilman, 4000, Liège, Belgium

    Julie Lecomte, Anne Masset & Agnès Noël

  2. School of Biological Sciences, University of East Anglia, NR4 7TJ, Norwich, UK

    Dylan R. Edwards

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  1. Julie Lecomte
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  2. Anne Masset
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  4. Agnès Noël
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Correspondence to Agnès Noël .

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  1. Siederstrasse 13, Villingen-Schwenningen, 78054, Germany

    Margareta M. Mueller

  2. Am Pferchelhang 32, Heidelberg, 69118, Germany

    Norbert E. Fusenig

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Lecomte, J., Masset, A., Edwards, D.R., Noël, A. (2011). Tumor Fibroblast-Associated Metalloproteases. In: Mueller, M., Fusenig, N. (eds) Tumor-Associated Fibroblasts and their Matrix. The Tumor Microenvironment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0659-0_10

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