An Evidence-based Perspective of Coptis Chinensis (Chinese Goldthread) for Cancer Patients

Chapter
Part of the Evidence-based Anticancer Complementary and Alternative Medicine book series (ACAM)

Abstract

Coptis chinensis (Chinese goldthread) and herbal complexes containing Chinese goldthread have been proven to possess anticancers effect in vitro and in vivo. Some herbal complexes containing Chinese goldthread, YiQiJueDu Granule (YQJDG), San-Huang-Xie-Xin Decoction, and ZuoJin Pill possess an inhibitory effect on nasopharyngeal carcinoma (NPC), HepG2, or S180 tumor cells, respectively. YQJDG’s inhibitory effects on NPC growth and nasopharyngeal carcinogenesis are associated with reducing-telomerase besides down-regulating cell cycle and inducing apoptosis genes expression. Specially, YQJDG also has a therapeutic effect on the population at high risk for NPC. As a main component of YQJDG, Chinese goldthread has an anticancer effect on NPC, leukemia, melanoma, epidermoid carcinoma, hepatoma, oral carcinoma, glioblastoma, prostate carcinoma, and gastric carcinoma. Berberine and coptisine are two major components of Chinese goldthread. Berberine exerts anticancer effects through modulating Mcl-1, Bcl-xL, COX-2, MDR, TNF-α, IL-6, iNOS, IL-12, intercellular adhesion molecule-1, ELAM-1, MCP-1, CINC-1, cyclin D1, AP-1, HIF-1α, PPAR-γ, topoisomerase II, and inhibiting stress-induced mitogen-activated protein kinase activation. Its mechanisms include inducing cell cycle arrest, apoptosis, antiangiogenic, and anti-metastasis. Berberine also has a therapeutic effect-enhancing and toxicity-reducing effect on other antitumor therapies and preventive effect on carcinogenesis. However, berberine possesses some potential toxicity and adverse effects. Coptisine exerts anticancer effect mainly via inhibiting vascular smooth muscle cell proliferation.

Keywords

Anticancer Effect CaSki Cell H1299 Human Lung Cancer Cell Evodia Rutaecarpa Vascular Smooth Muscle Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported in part by the National Natural Science Foundation of China (30973400, 81071718).

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Faqing Tang
    • 1
    • 2
  • Wenhua Mei
    • 1
  • Daofa Tian
    • 3
  • Damao Huang
    • 4
  1. 1.The Third Affiliated Hospital of Jinan UniversityZhuhaiPeople’s Republic of China
  2. 2.Xiangya HospitalCentral South UniversityChangshaPeople’s Republic of China
  3. 3.The First Affiliated HospitalTraditional Chinese Medicine University of HunanChangshaPeople’s Republic of China
  4. 4.Xiangya Hospital of Central South UniversityChangshaPeople’s Republic of China

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