An Evidence-based Perspective of Coptis Chinensis (Chinese Goldthread) for Cancer Patients

  • Faqing Tang
  • Wenhua Mei
  • Daofa Tian
  • Damao Huang
Part of the Evidence-based Anticancer Complementary and Alternative Medicine book series (ACAM)


Coptis chinensis (Chinese goldthread) and herbal complexes containing Chinese goldthread have been proven to possess anticancers effect in vitro and in vivo. Some herbal complexes containing Chinese goldthread, YiQiJueDu Granule (YQJDG), San-Huang-Xie-Xin Decoction, and ZuoJin Pill possess an inhibitory effect on nasopharyngeal carcinoma (NPC), HepG2, or S180 tumor cells, respectively. YQJDG’s inhibitory effects on NPC growth and nasopharyngeal carcinogenesis are associated with reducing-telomerase besides down-regulating cell cycle and inducing apoptosis genes expression. Specially, YQJDG also has a therapeutic effect on the population at high risk for NPC. As a main component of YQJDG, Chinese goldthread has an anticancer effect on NPC, leukemia, melanoma, epidermoid carcinoma, hepatoma, oral carcinoma, glioblastoma, prostate carcinoma, and gastric carcinoma. Berberine and coptisine are two major components of Chinese goldthread. Berberine exerts anticancer effects through modulating Mcl-1, Bcl-xL, COX-2, MDR, TNF-α, IL-6, iNOS, IL-12, intercellular adhesion molecule-1, ELAM-1, MCP-1, CINC-1, cyclin D1, AP-1, HIF-1α, PPAR-γ, topoisomerase II, and inhibiting stress-induced mitogen-activated protein kinase activation. Its mechanisms include inducing cell cycle arrest, apoptosis, antiangiogenic, and anti-metastasis. Berberine also has a therapeutic effect-enhancing and toxicity-reducing effect on other antitumor therapies and preventive effect on carcinogenesis. However, berberine possesses some potential toxicity and adverse effects. Coptisine exerts anticancer effect mainly via inhibiting vascular smooth muscle cell proliferation.


Anticancer Effect CaSki Cell H1299 Human Lung Cancer Cell Evodia Rutaecarpa Vascular Smooth Muscle Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported in part by the National Natural Science Foundation of China (30973400, 81071718).


  1. Anis, K. V., Rajeshkumar, N. V., & Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. The Journal of Pharmacy and Pharmacology, 53, 763–768.PubMedCrossRefGoogle Scholar
  2. Auyeung, K. K., & Ko, J. K. (2009). Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation. International Journal of Molecular Medicine, 24, 571–577.PubMedGoogle Scholar
  3. Chen, W. H., Qin, Y., Cai, Z., et al. (2005). Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA. Bioorganic & Medicinal Chemistry, 13, 1859–1866.CrossRefGoogle Scholar
  4. Chen, T. C., Lai, K. C., Yang, J. S., et al. (2009). Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. International Journal of Oncology, 34, 1681–1690.PubMedGoogle Scholar
  5. Cheng, W. Y., Wu, S. L., Hsiang, C. Y., et al. (2008). Relationship between San-Huang-Xie-Xin-Tang and its herbal components on the gene expression profiles in HepG2 cells. The American Journal of Chinese Medicine, 36, 783–797.PubMedCrossRefGoogle Scholar
  6. Choi, B. H., Ahn, I. S., Kim, Y. H., et al. (2006). Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Experimental & Molecular Medicine, 38, 599–605.CrossRefGoogle Scholar
  7. Choi, M. S., Yuk, D. Y., Oh, J. H., et al. (2008). Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis. Anticancer Research, 28, 3777–3784.PubMedGoogle Scholar
  8. Choi, M. S., Oh, J. H., Kim, S. M., et al. (2009). Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. International Journal of Oncology, 34, 1221–1230.PubMedCrossRefGoogle Scholar
  9. Colombo, M. L., Bugatti, C., Mossa, A., et al. (2001). Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine. Farmaco, 56, 403–409.PubMedCrossRefGoogle Scholar
  10. Cui, H. S., Hayasaka, S., Zheng, L. S., et al. (2007). Effect of berberine on monocyte chemotactic protein-1 and cytokine-induced neutrophil chemoattractant-1 expression in rat lipopolysaccharide-induced uveitis. Ophthalmic Research, 39, 32–39.PubMedCrossRefGoogle Scholar
  11. Doggrell, S. A. (2005). Berberine—A novel approach to cholesterol lowering. Expert Opinion on Investigational Drugs, 14, 683–685.PubMedCrossRefGoogle Scholar
  12. Eom, K. S., Hong, J. M., Youn, M. J., et al. (2008). Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway. Biological & Pharmaceutical Bulletin, 31, 558–562.CrossRefGoogle Scholar
  13. Franzblau, S. G., & Cross, C. (1986). Comparative in vitro antimicrobial activity of Chinese medicinal herbs. Journal of Ethnopharmacology, 15, 279–288.PubMedCrossRefGoogle Scholar
  14. Fukuda, K., Hibiya, Y., Mutoh, M., et al. (1999). Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. Journal of Ethnopharmacology, 66, 227–233.PubMedCrossRefGoogle Scholar
  15. Harikumar, K. B., Kuttan, G., & Kuttan, R. (2008). Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products—Berberine, curcumin and picroliv. Journal of Experimental Therapeutics & Oncology, 7, 275–284.Google Scholar
  16. Ho, Y. T., Lu, C. C., Yang, J. S., et al. (2009a). Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells. Anticancer Research, 29, 4063–4070.Google Scholar
  17. Ho, Y. T., Yang, J. S., Li, T. C., et al. (2009b). Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Cancer Letters, 279, 155–162.CrossRefGoogle Scholar
  18. Ho, Y. T., Yang, J. S., Lu, C. C., et al. (2009c). Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. Phytomedicine, 16, 887–890.CrossRefGoogle Scholar
  19. Hsieh, Y. S., Kuo, W. H., Lin, T. W., et al. (2007). Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells. Journal of Agricultural and Food Chemistry, 55, 10437–10445.PubMedCrossRefGoogle Scholar
  20. Hsu, W. H., Hsieh, Y. S., Kuo, H. C., et al. (2007). Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. Archives of Toxicology, 81, 719–728.PubMedCrossRefGoogle Scholar
  21. Huang, C., Zhang, Y., Gong, Z., et al. (2006). Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochemical and Biophysical Research Communications, 348, 571–578.PubMedCrossRefGoogle Scholar
  22. Hung, T. M., Lee, J. P., Min, B. S., et al. (2007). Magnoflorine from Coptidis rhizoma protects high density lipoprotein during oxidant stress. Biological & Pharmaceutical Bulletin, 30, 1157–1160.CrossRefGoogle Scholar
  23. Hur, J. M., Hyun, M. S., Lim, S. Y., et al. (2009). The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells. Journal of Cellular Biochemistry, 107, 955–964.PubMedCrossRefGoogle Scholar
  24. Hwang, J. M., Kuo, H. C., Tseng, T. H., et al. (2006). Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells. Archives of Toxicology, 80, 62–73.PubMedCrossRefGoogle Scholar
  25. Iizuka, N., Miyamoto, K., Hazama, S., et al. (2000). Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6. Cancer Letters, 158, 35–41.PubMedCrossRefGoogle Scholar
  26. Jung, H. A., Yoon, N. Y., Bae, H. J., et al. (2008). Inhibitory activities of the alkaloids from Coptidis rhizoma against aldose reductase. Archives of Pharmacal Research, 31, 1405–1412.PubMedCrossRefGoogle Scholar
  27. Kang, M. R., & Chung, I. K. (2002). Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine. Molecular Pharmacology, 61, 879–884.PubMedCrossRefGoogle Scholar
  28. Kang, B. Y., Chung, S. W., Cho, D., et al. (2002). Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid. Biochemical Pharmacology, 63, 1901–1910.PubMedCrossRefGoogle Scholar
  29. Katiyar, S. K., Meeran, S. M., Katiyar, N., et al. (2009). p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Molecular Carcinogenesis, 48, 24–37.PubMedCrossRefGoogle Scholar
  30. Kettmann, V., Kosfalova, D., Jantova, S., et al. (2004). In vitro cytotoxicity of berberine against HeLa and L1210 cancer cell lines. Pharmazie, 59, 548–551.PubMedGoogle Scholar
  31. Kim, S., Choi, J. H., Kim, J. B., et al. (2008). Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cells. Molecules, 13, 2975–2985.PubMedCrossRefGoogle Scholar
  32. Kim, J. B., Yu, J. H., Ko, E., et al. (2010). The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest. Phytomedicine, 17, 436–440.PubMedCrossRefGoogle Scholar
  33. Ko, W. H., Yao, X. Q., Lau, C. W., et al. (2000). Vasorelaxant and antiproliferative effects of berberine. European Journal of Pharmacology, 399, 187–196.PubMedCrossRefGoogle Scholar
  34. Kuo, C. L., Chi, C. W., & Liu, T. Y. (2004). The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Letters, 203, 127–137.PubMedCrossRefGoogle Scholar
  35. Kuo, C. L., Chi, C. W., & Liu, T. Y. (2005). Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo, 19, 247–252.PubMedGoogle Scholar
  36. Letasiova, S., Jantova, S., & Muckova, M. (2005). Antiproliferative activity of berberine in vitro and in vivo. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia Republic, 149, 461–463.CrossRefGoogle Scholar
  37. Letasiova, S., Jantova, S., Cipak, L., et al. (2006). Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. Cancer Letters, 239, 254–262.PubMedCrossRefGoogle Scholar
  38. Li, H., Guo, L., Jie, S., et al. (2008). Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells. Biomedical Pharmacotherapy, 62, 573–578.CrossRefGoogle Scholar
  39. Lin, H. L., Liu, T. Y., Wu, C. W., et al. (1999). Berberine modulates expression of mdr1 gene product and the responses of digestive track cancer cells to Paclitaxel. British Journal of Cancer, 81, 416–422.PubMedCrossRefGoogle Scholar
  40. Lin, C. C., Ng, L. T., Hsu, F. F., et al. (2004a). Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clinical and Experimental Pharmacology & Physiology, 31, 65–69.CrossRefGoogle Scholar
  41. Lin, S., Tsai, S. C., Lee, C. C., et al. (2004b). Berberine inhibits HIF-1alpha expression via enhanced proteolysis. Molecular Pharmacology, 66, 612–619.Google Scholar
  42. Lin, C. C., Kao, S. T., Chen, G. W., et al. (2006a). Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Reseaerch, 26, 227–242.Google Scholar
  43. Lin, C. C., Lin, S. Y., Chung, J. G., et al. (2006b). Down-regulation of cyclin B1 and up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle. Anticancer Research, 26, 1097–1104.Google Scholar
  44. Lin, J. P., Yang, J. S., Lee, J. H., et al. (2006c). Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World Journal of Gastroenterology, 12, 21–28.Google Scholar
  45. Lin, C. C., Yang, J. S., Chen, J. T., et al. (2007a). Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. Anticancer Research, 27, 3371–3378.Google Scholar
  46. Lin, J. P., Yang, J. S., Chang, N. W., et al. (2007b). GADD153 mediates berberine-induced apoptosis in human cervical cancer Ca ski cells. Anticancer Research, 27, 3379–3386.Google Scholar
  47. Lin, J. P., Yang, J. S., Wu, C. C., et al. (2008a). Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro. In Vivo, 22, 223–230.Google Scholar
  48. Lin, T. H., Kuo, H. C., Chou, F. P., et al. (2008b). Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer, 8, 58.CrossRefGoogle Scholar
  49. Liu, J., He, C., Zhou, K., et al. (2009). Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells. Biochemical and Biophysical Research Communications, 378, 174–178.PubMedCrossRefGoogle Scholar
  50. Mantena, S. K., Sharma, S. D., & Katiyar, S. K. (2006). Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Molecular Cancer Therapeutics, 5, 296–308.PubMedCrossRefGoogle Scholar
  51. Meeran, S. M., Katiyar, S., & Katiyar, S. K. (2008). Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. Toxicology and Applied Pharmacology, 229, 33–43.PubMedCrossRefGoogle Scholar
  52. Mitani, N., Murakami, K., Yamaura, T., et al. (2001). Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. Cancer Letters, 165, 35–42.PubMedCrossRefGoogle Scholar
  53. Nishino, H., Kitagawa, K., Fujiki, H., et al. (1986). Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin. Oncology, 43, 131–134.PubMedCrossRefGoogle Scholar
  54. Ouyang, Z., Li, Z. Y., & Yuan, W. H. (1999). An observation on therapeutic effect of Copitis chenesis and Scutellaria baicalensis on EBV-VCA/IgA of patients with nasopharyngeal carcinoma precancer. Chinese Journal of Integrated Traditional and Western Medicine, 7, 167–168.Google Scholar
  55. Pandey, M. K., Sung, B., Kunnumakkara, A. B., et al. (2008). Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Research, 68, 5370–5379.PubMedCrossRefGoogle Scholar
  56. Peng, P. L., Hsieh, Y. S., Wang, C. J., et al. (2006). Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicology and Applied Pharmacology, 214, 8–15.PubMedCrossRefGoogle Scholar
  57. Peng, P. L., Kuo, W. H., Tseng, H. C., et al. (2008). Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: The contribution of autophagic cell death. International Journal of Radiation Oncology, Biology, Physics, 70, 529–542.PubMedCrossRefGoogle Scholar
  58. Pereira, G. C., Branco, A. F., Matos, J. A., et al. (2007). Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9, 10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: Comparison with direct effects on isolated mitochondrial fractions. The Journal of Pharmacology and Experimental Therapeutics, 323, 636–649.PubMedCrossRefGoogle Scholar
  59. Pinto-Garcia, L., Efferth, T., Torres, A., et al. (2010). Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells. Planta Medica, 76, 1155–1161.PubMedCrossRefGoogle Scholar
  60. Rackova, L., Majekova, M., Kost’alova, D., et al. (2004). Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects. Bioorganic & Medicinal Chemistry, 12, 4709–4715.CrossRefGoogle Scholar
  61. Ro, J. S., Lee, S. S., Lee, K. S., et al. (2001). Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life Science, 70, 639–645.CrossRefGoogle Scholar
  62. Sanders, M. M., Liu, A. A., Li, T. K., et al. (1998). Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells. Biochemical Pharmacology, 56, 1157–1166.PubMedCrossRefGoogle Scholar
  63. Serafim, T. L., Oliveira, P. J., Sardao, V. A., et al. (2008). Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line. Cancer Chemotherapy and Pharmacology, 61, 1007–1018.PubMedCrossRefGoogle Scholar
  64. Sun, J., Ma, J. S., Jin, J., et al. (2006). Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS. Yao Xue Xue Bao (Acta pharmaceutica Sinica), 41, 380–384.Google Scholar
  65. Suzuki, H., Tanabe, H., Mizukami, H., et al. (2010). Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine. Biological & Pharmaceutical Bulletin, 33, 677–682.CrossRefGoogle Scholar
  66. Tan, Y., Ming, Z., Tang, Q., et al. (2005). Effect of berberine on the mRNA expression of nitric oxide synthase (NOS) in rat corpus cavernosum. Journal of Huazhong University of Science and Technology. Medical Sciences, 25, 127–130.CrossRefGoogle Scholar
  67. Tanabe, H., Suzuki, H., Mizukami, H., et al. (2005). Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells. Biochemical Pharmacology, 70, 1176–1184.PubMedCrossRefGoogle Scholar
  68. Tanabe, H., Suzuki, H., Nagatsu, A., et al. (2006). Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in. Phytomedicine, 13, 334–342.PubMedCrossRefGoogle Scholar
  69. Tang, F. Q., & Tian, D. F. (1995). Study on dynamics of Zhizoma Coptidis and its complex to kill human nasopharyngeal carcinoma cell. Journal of Hunan College of Traditional Chinese Medicine, 15, 41–44.Google Scholar
  70. Tang, F. Q., & Tian, D. F. (1996). Morphological observation on Rhizoma Copidis and its complex to kill nasopharyngeal carcinoma cells. Journal of Hunan College of Traditional Chinese Medicine, 16, 46–48.Google Scholar
  71. Tang, F. Q., Jiang, H. Y., Duan, C. J., et al. (2001a). Profile of telomerase and telomerase RNA expression in nasopharyngeal carcinogenesis of rats induced by N, N′dinitrosopiperazine (DNP). Chinese Journal of Pathology, 30, 125–128.Google Scholar
  72. Tang, F. Q., Tian, D. F., Chen, C. H., et al. (2001b). Inhibitory effect of YiQiJieDu power to telomerase and telomerase RNA in nasopharyngeal tumorigenesis. Bulletin of Hunan Medical University, 26, 301–304.Google Scholar
  73. Tang, F. Q., Gong, Z. J., Zhou, H., et al. (2004a). Gene expression analysis of the implanted-tumor of nasopharngeal carcinoma treated by YiQiJieDu granule using human cancer cDNA array. Practical Preventive Medicine, 11, 637–640.Google Scholar
  74. Tang, F. Q., Tian, D. F., Deng, F. L., et al. (2004b). Effect of YiQiJieDu granule on the implanted-tumor protein expression in nasopharyngeal carcinoma. Bulletin of Hunan Medical University, 29, 577–582.Google Scholar
  75. Tang, L. Q., Wei, W., Chen, L. M., et al. (2006). Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. Journal of Ethnopharmacology, 108, 109–115.PubMedCrossRefGoogle Scholar
  76. Tang, F. Q., Wang, D. S., Duan, C. J., et al. (2009a). Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567. The Journal of Biological Chemistry, 284, 27456–27466.CrossRefGoogle Scholar
  77. Tang, J., Feng, Y., Tsao, S., et al. (2009b). Berberine and Coptidis rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations. Journal of Ethnopharmacology, 126, 5–17.CrossRefGoogle Scholar
  78. Tao, Z. D., & Tian, D. F. (2001). Observation of therapeutic effect in prerenting and treating pharyngeal mucous reaction dueto radiotherapy with YiQiYangYin Fang. Journal of Hunan College of Traditional Chinese Medicine, 13, 20–21.Google Scholar
  79. Thirupurasundari, C. J., Padmini, R., & Devaraj, S. N. (2009). Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats. Chemico-Biological Interactions, 177, 190–195.PubMedCrossRefGoogle Scholar
  80. Tian, D. F., Tang, F. Q., Chen, X. Y., et al. (2000). A clinical observation of YIJIEDU granule’s inhibitory effect on the EBV activity in population at nasopharyngeal carcinoma risk. Journal of Hunan College of Traditional Chinese Medicine, 20, 47–49.Google Scholar
  81. Tsang, C. M., Lau, E. P., Di, K., et al. (2009). Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells. International Journal of Molecular Medicine, 24, 131–138.PubMedGoogle Scholar
  82. Wang, D. H., & Tian, D. F. (2006). A clinical observation of radiotherapy and YIQIJIEDU granule treatment on nasopharyngeal carcinoma. Journal of Hunan College of Traditional Chinese Medicine, 26, 36–38.Google Scholar
  83. Wang, G. P., Tang, F. Q., & Zhou, J. P. (2003). Effect of Coptis Chinensis compound on the gene expression in transplanted tumor tissue in nasopharyngeal carcinoma cell line of CNE1 by cDNA microarray. Hunan Yi Ke Da Xue Xue Bao, 28, 347–352.PubMedGoogle Scholar
  84. Wang, X. N., Xu, L. N., Peng, J. Y., et al. (2009). In vivo inhibition of S180 tumors by the synergistic effect of the Chinese medicinal herbs Coptis chinensis and Evodia rutaecarpa. Planta Medica, 75, 1215–1220.PubMedCrossRefGoogle Scholar
  85. Wartenberg, M., Budde, P., De Marees, M., et al. (2003). Inhibition of tumor-induced angiogenesis and matrix-metalloproteinase expression in confrontation cultures of embryoid bodies and tumor spheroids by plant ingredients used in traditional chinese medicine. Laboratory Investigation, 83, 87–98.PubMedCrossRefGoogle Scholar
  86. Yang, L. Q., Singh, M., Yap, E. H., et al. (1996). In vitro response of Blastocystis hominis against traditional Chinese medicine. Journal of Ethnopharmacology, 55, 35–42.PubMedCrossRefGoogle Scholar
  87. Yokozawa, T., Satoh, A., Cho, E. J., et al. (2005). Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells. The Journal of Pharmacy Pharmacology, 57, 367–374.CrossRefGoogle Scholar
  88. Yount, G., Qian, Y., Moore, D., et al. (2004). Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro. Journal of Experimental Therapeutics & Oncology, 4, 137–143.Google Scholar
  89. Yu, F. S., Yang, J. S., Lin, H. J., et al. (2007). Berberine inhibits WEHI-3 leukemia cells in vivo. In Vivo, 21, 407–412.PubMedGoogle Scholar
  90. Zhang, L., Yang, L., & Zheng, X. (1997). A study of Helicobacterium pylori and prevention and treatment of chronic atrophic gastritis. Journal of Traditional Chinese Medicine, 17, 3–9.PubMedGoogle Scholar
  91. Zhao, X., Zhang, J. J., Wang, X., et al. (2008). Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital- treated rats. Biomedicine & Pharmacotherapy, 62, 567–572.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Faqing Tang
    • 1
    • 2
  • Wenhua Mei
    • 1
  • Daofa Tian
    • 3
  • Damao Huang
    • 4
  1. 1.The Third Affiliated Hospital of Jinan UniversityZhuhaiPeople’s Republic of China
  2. 2.Xiangya HospitalCentral South UniversityChangshaPeople’s Republic of China
  3. 3.The First Affiliated HospitalTraditional Chinese Medicine University of HunanChangshaPeople’s Republic of China
  4. 4.Xiangya Hospital of Central South UniversityChangshaPeople’s Republic of China

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